Objective
Orally administered bioactive peptides are largely degraded during gastrointestinal digestion. This study examines the possibilities to use milk proteins to deliver bioactive peptides in an active form to target tissues through the intestinal mucosa and thus enhance biological activities of these important compounds. This would have a great impact on preventing the major health risks in the population, such as hypertension, obesity and the metabolic syndrome. Bioactive peptides examined in this project will be chosen based on their favourable biological effects and characteristics that allow them to bind to the carrier proteins.
The carrier proteins used in this study are milk proteins, primarily beta-lactoglobulin and natural and mutated caseins. The complexes formed will be characterized by molecular modelling, ultra-filtration and isothermal titration calorimetry (ITC) and their resistance against gastrointestinal degradation will be assessed. Promising protein-peptide complexes will be chosen for further structural studies.
Finally, the passage of the carrier proteins complexed with the bioactive peptides through enterocytes and M-cell monolayers will be examined, and preservation of biological activity analysed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences analytical chemistry calorimetry
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OULU
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.