Objective
Development of multi-cellular organisms is an ideal model to study the sources contributing to phenotypic variation, such as disease susceptibility, agriculturally or evolutionarily important features. The corollary question, regarding factors that contribute to the robustness of development and phenotypic stability, is however under-appreciated.
The project aims to identify factors that influence the variation and stability of transcription of genes regulating the early development in Drosophila (an unparalleled model species). To this end, several steps will and have been taken. Firstly, population samples show that there is considerable variation in regulatory sequences within D. melanogaster, with several mutations affecting DNA known to be important for expression. The plan is to extend this survey to more genes and survey additional species. Secondly, the focus is on the intrinsic noise in expression, and testing explicitly the novel hypothesis that somatic mutations in the DNA binding domains of Transcription factor proteins contribute. The third component relates to the second, and centres on testing the utility of fruitflies as a model species to study somatic mutations at the DNA level.
A combination of cutting edge population and experimental genetics will be applied to study the stability of development in this unique system. This can identify the factors affecting stability and variation in phenotypes, and by testing the effects of somatic mutations, the study is designed to improve our understanding of the material basis of cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
REYKJAVIK
Iceland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.