Objective
This research project will test two highly controversial and scantily researched hypotheses in the neuropscience of memory:
- that the extended hippocampal system (EHS) is always needed for recollective processes, as opposed to familiarity, regardless of memory age;
- that under certain conditions, the neocortex can support new declarative learning independently of the EHS.
These contradict the prevailing view that all remote memories are independent of the hippocampus, and that the neocortex cannot support new declarative learning. Patients with specific EHS lesions and patients with extensive Medial Temporal Lobe (MTL) lesions will be tested on recognition memory of personal events, using Remember/Know (RK) distinctions, Receiver Operating Characteristic (ROC) curves, and Process Dissociation Paradigms (PDP).
PDP and ROC have never been used to study remote memory, and only they can provide objective measures of recollection/familiarity. It is expected that EHS patients will show a specific deficit on recollection, regardless of memory age, whereas MTL patients will show deficits on both components. Neuroimaging of patients and healthy controls will provide converging evidence for the distinct role of the EHS in recollection, regardless of memory age.
To test patients' ability to acquire new declarative information, a Fast Mapping (FM) paradigm derived from the developmental literature on the acquisition of language will be used. FM allows children to acquire large amounts of associative information, presumably capitalizing on neocortical plasticity and independently of the EHS.
If residual neocortical plasticity underlies amnesic patients' observed ability to learn new semantic information, then they should also succeed on FM tasks. Neuroimaging will confirm that FM learning is independent of the EHS. The results of this project will have far reaching implications for memory theory and memory rehabilitation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine physiotherapy
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HAIFA
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.