Objective
Planar cell polarity (PCP) genes were originally identified in invertebrates (Drosophila Melanogaster) for their role in the uniform orientation of a cell or a group of cells within the plane of the epithelium. During the last five years, numerous studies have shown that vertebrate, but more importantly mammalian homologues of some of these genes are involved in various developmental processes.
More importantly, the disruption of these processes leads to diverse pathologies such as neural tube defects, polycystic kidney disease, inner ear dysfunctions (hearing, balance) or Bardet Biedl syndrome. These developmental processes rely on a set of genes whose PCP function is conserved in mammals and Drosophila Melanogaster for some, or only present in mammals for others. We have identified Scrb1 and Vangl2 as two essential genes for the PCP in mammals, and have recently demonstrated that the two proteins belong to a common signalling pathway in vitro and in vivo.
We also showed, with another group, that some of the very upstream mechanisms of the PCP pathway seem different from invertebrates. In fact, the exact nature of the intracellular components participating in the intracellular cascade leading to the establishment of PCP is virtually unknown in mammals. It is now important to identify not only genes involved in PCP in mammals, but also the intracellular signalling cascades leading to the establishment of that PCP.
Our project will use a multidisciplinary approach, combining biochemistry to further identify binding partners for Vangl2 and Scrb1, and genetics, cell biology and imaging procedures to characterize these interactions at the functional level. We hope that this project, in the long term, will give a much better understanding of the signalling pathway centred on the Vangl2-Scrb1 module in mammals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell polarity
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.