Final Activity Report Summary - GAMMADELTA HOMING (Analysis of the mechanisms that direct gamma-delta T cell homing and function)
The host Institute of Immunology at the Hannover Medical School under the direction of Prof. Dr Reinhold Förster has an outstanding record in the field of leukocyte migration. Moreover, the department of Prof. Dr Reinhold Förster is firmly connected to the main research and education networks in the area of Hannover. The fellow, Dr Immo Prinz, had during his EIF Marie Curie fellowship in France worked in the field of unconventional T cells, in particular gamma-delta T cells. During that period, which was hosted by Dr Bernard Malissen at the Centre d'Immunologie de Marseille-Luminy, he had developed a mouse model that simplifies the analysis of gamma-delta T cells.
The scientific objectives of this European Re-integration Grant were to investigate the homing and migration properties of gamma-delta T cells. Therefore, the aforementioned and other mouse models were transferred to the Institute of Immunology in Hannover. Now combining the scientific and technical excellence of the host laboratory in the field of leukocyte migration and the sophisticated mouse models generated during the EIF fellowship, we have started to thoroughly investigate the homing and migration properties of gamma-delta T cells. Our first results show that this undertaking is feasible and that it will advance our understanding of gamma-delta T cell biology.
The formal objective of this European Re-integration Grant was to effectively re-integrate the fellow into the German biomedical research landscape. This goal has been accomplished by providing the fellow Dr Immo Prinz with a three year contract to establish his own research group within the department of Immunology. In this situation, the 12 months support of the Marie Curie ERG served as valuable start-up funding. Future continuation of this research project is now assured, because Dr Immo Prinz has during his first year in Hannover managed to obtain two research grants to support his research at the Hannover Medical School beyond this period.
The scientific objectives of this European Re-integration Grant were to investigate the homing and migration properties of gamma-delta T cells. Therefore, the aforementioned and other mouse models were transferred to the Institute of Immunology in Hannover. Now combining the scientific and technical excellence of the host laboratory in the field of leukocyte migration and the sophisticated mouse models generated during the EIF fellowship, we have started to thoroughly investigate the homing and migration properties of gamma-delta T cells. Our first results show that this undertaking is feasible and that it will advance our understanding of gamma-delta T cell biology.
The formal objective of this European Re-integration Grant was to effectively re-integrate the fellow into the German biomedical research landscape. This goal has been accomplished by providing the fellow Dr Immo Prinz with a three year contract to establish his own research group within the department of Immunology. In this situation, the 12 months support of the Marie Curie ERG served as valuable start-up funding. Future continuation of this research project is now assured, because Dr Immo Prinz has during his first year in Hannover managed to obtain two research grants to support his research at the Hannover Medical School beyond this period.