Objective
The aim of this proposal is to investigate the physiological relevance of the molecular circadian clockwork expressed in peripheral organs. This question will be addressed in a new and original paradigm: the endocrine pituitary gland. Indeed, several so-called clock genes that form the molecular cogwheels of the biological clock have recently been identified. Surprisingly, besides being activated in structures known to host an internal clock (namely the suprachiasmatic nuclei, SCN, in mammals) they are also expressed in many -if not all- other tissues, among which the pituitary gland where strong oscillations of the clock machinery have been found. Using mutant mice that bear an altered clock, we will research the impact of the clock upon several key parameters of the gland physiology such as electrical activity of endocrine cells and hormonal secretion in basal and stimulated conditions.
This project constitutes the frame of a stable research position of the applicant in his native country. It will be achieved thanks to several scientific collaborations at the national, European and worldwide levels. Results obtained from this research are expected to answer critical questions in fundamental chronobiology and cell biology but also, the understanding of the fine mechanisms that pace the daily functioning of organs may have potential important outcomes in modern medicine, e.g. development of chronotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine physiology
- medical and health sciences clinical medicine endocrinology
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.