Objective
Chromosomal ends have protective structures named telomeres that distinguish them from broken chromosomes. Telomeres are composed of tandem G-rich DNA repeats bound to an array of proteins that are essential for telomere capping. The synthesis of telomeres by telomerase and their function are proposed to be biological determinants in the process of cancer and aging. Telomere dysfunction because of short telomeres or mutation of telomere-binding proteins can lead to chromosomal end-to-end fusions and loss of cell viability. I will test the relevance of telomeres and telomerase in tumour development and aging using mouse models deficient for proteins that are important for telomere function, such as telomerase (Tere knock-out mice) and telomeric binding proteins (Ku86 and DNA-PKcs knock-out mice). Further I will study transgenic mice overexpressing the catalytic subunit of telomerase (mTert) in adult tissues that normally lack telomerase to directly analyse the impact of telomerase upregulation for tumour growth and ageing. I will test whether telomerase cooperates with loss of p53 in tumorigenesis using telomerase transgenic p53 knockout mice. Additionally I will evaluate the role of telomeres and telomerase in tumourigenesis by analysing double mutant mice lacking telomerase, with an activatingCdk4 R24C mutation, present in human hereditary melanoma. The analysis of these different mouse models should help to understand the function of telomerase intelomere maintenance, cancerogenesis and age-associated diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics chromosomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.