Objective
Coronary artery disease, the primary cause of death in the western world, is induced by an acute cessation of the blood flow due to the formation of an occluded thrombus or blood clotin or nearby an unstable atherosclerotic lesion. Whether or not thrombotic complications will ensue from plaque rupture is strongly dependent on the presence of procoagulant molecules within the plaque. Interference with their activity thus represents a promising approach to influence the initiation and progression of the disease. The general goal of the project is:
- to inhibit expression and activity of procoagulant proteins by delivering specific enzymes and,
- to modulate the activity of transcription factors regulating these proteins.
Modulation will be effected by atherosclerotic plaque-directed adenoviral gene transfer, bone marrow transplantation from corresponding transgenics and administration of therapeutic inhibitors in an advanced mouse model of accelerated atherosclerosis. The effect on the plaque size and morphology as well as on its lipid content and thrombotic nature will be determined. We anticipate that the results will lead to new therapeutic entries for reducing the thrombogenicity of atherosclerotic plaques and thus preventing thrombotic complications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine transplantation
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.