Objective
Complex I or NADH: quinone oxidoreductase is the first of 4 membrane-bound enzyme complexes that actively participate in the oxidative phosphorylation process, Electrons transferred from NADH are coupled to proton translocation across a membrane and the resulting electrochemical proton gradient is used to generate ATP. The eucharistic complex I, with about 45 different subunits and over 900 kea, contains one-Man molecule, up to nine Fe/S clusters and at least three-bound quoin! Molecules. Homologs of complex I are present in a vast number of organisms and in prokaryotes their architectures considerably simpler than in eucalypts. Consisting of only 14 subunits, but retaining an equivalent set of cofactors, they represent the minimal requirement for a functional complex I. So far, only a low-resolution 3-Decry electron microscopy structure of complex I am available, showing an L-shaped structure that is conserved between eucalypts and prokaryotes. It is also commonly assumed that complex I have evolved from pre-existing modules for proton translocation and electron transfer. Descriptions of complex I as a \\\\\\\"big black box\\\\\\\" am often found in the literature. Understanding its mechanism is a fundamental challenge in bioenergetics with strong repercussions in medicine. Obtaining structural information on complex I is crucial step towards that goal. However, so far the limited availability of pure and stable material has not allowed for growing suitable crystals for 3-D structure determination by X-ray crystallography. We propose, like it was done in the case of the ribosome, to start out towards getting a complete picture of complex I by looking at isolated subunits or sub complexes and assemble them later with the help of cry electron microscopy images or lower-resolution crystal structures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GOETTINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.