Objective
The present research project is aimed to the design of molecular devices suitable for the optical detection of electrically charged and neutral guests. In particular, we intend to prepare dual responsive sensing devices, which are able to communicate to the outside, the occurrence of the recognition event through two distinct and independent channels:
(i) colour change and
(ii) modification of the fluorescence emission. This goal will be achieved by using as a signalling subunit a molecular fragment, which are both a chromospheres and a fluorophore. This dual responsive feature will be especially useful for the real space and the real time determination of analyses in systems like the whole cell and tissues, when investigated by optical co focal microscopy. Sensing devices will be designed for the following classes of analyses: metal ions, anions, amino acids, and small molecules like NO and CO. Two distinct paradigms will be followed for the design of the molecular sensor:
(i) the covalent linking approach (the receptor moiety and the signalling subunit are covalently linked together, either directly or through a spacer);
(ii) the chemo sensing ensemble approach, which involves the weak and reversible interaction of the receptor with an optical indicator, to be displaced by the desired analyse. Either approach will be used depending upon the nature of the substrate. For the detection of transition metal ions, multidentate legends will be used as receptors. The nature of the chelating subunit, whether open or cyclic, will define the type of sensing device: with an open-chain receptor, metal binding will occur in a fully reversible way, thus giving rise to a sensor, if the receptor is cyclic, the metal will be included irreversibly into the macro cyclic cavity, thus producing a dosimeter, i.e. a permanent device, which accumulates the dose and sums up the signal.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering colors
- natural sciences physical sciences optics microscopy
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PAVIA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.