Objective
The aim is to synthesise a series of novel biodegradable polymers consisting of polyoxonorbornene backbones with poly (hydroxyacid) side chains, and to study the variation in physical and mechanical properties of these polymers as a function of degradation under simulated biological conditions. A series of mono- and did-alcohol substituted oxonorbornenes will be synthesised and used as initiators for the ring opening polymerisation of lactate and glycoside to make oxonorbornenyl polyhydroxyacid macro monomers which will then be subjected to ring opening metathesis polymerisation (ROMP) to prepare the target biodegradable polymers. This synthetic approach will give complete control of the side chain and backbone chain lengths. This strategy will allow the study of variables such as the nature of the ROMP fragment, the length and composition of the degradable side chain, the size of the backbone, and the side chain density of the polymer prior to degradation. This project brings together a multi-disciplinary research team to develop bioresorbable polymers, which degrade in such a way that their mechanical properties change gradually from a rigid material to an increasingly flexible material before bioresorption is complete. In this way increasing load is introduced gradually onto the supported bone or tissue, which aids the healing process. This feature, combined with good mechanical properties on implantation would lead to the use of these materials in biomedical applications such as temporary hard and soft tissue fixation. Current implant polymers (polylactide, polyglycolide) do not provide this behaviour, with mass loss resulting in relatively sudden loss of mechanical properties on degradation, but no continuum of change from inelastic to elastic behaviour. The medical device industry as a whole will benefit from the outcome of this new class of materials from which to fashion devices for patient benefit.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology industrial biotechnology biomaterials bioplastics polylactic acid
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences polymer sciences
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DURHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.