Objective
It is proposed to examine the synthesis or novel diporphyrazme systems derived from the crossed Instead macrocyclisation reactions of diaminomaleonitrile derivatives with biphenyl-2, 2,3,3-tetranitrile or tetracyanoethylene. The resulting porphyrazines are expected to show red-shifted UV-visspectra with the long wavelength Q bands above 700 nm. In addition, these porphyrazines should be precursor molecules for the preparation of the structurally related seco-porphyrazines. Thesemacrocycles will be assayed as probe molecules for the detection of cancers and as probe molecules in studies of cell differentiation. The seco-porphyrazines should be effective imaging agents and/ortargetable sensitises for singled oxygen generation for the photodynamic therapy of cancer and infectious diseases. The proposed work is relevant for the development of novel diagnostic and therapeutic agents with diverse medical applications. Amongst legions of diseases, one illustration will suffice: breast cancer is the leading cause of death amongst EU and US women in the age range 40-49.Unfortunately the current technique of annual mammograms is insufficiently reliable with significant levels of "false-positives" and the more sinister "false-negatives." Clearly, there is the need for more reliable yet non-invasive imaging methods. Optical imaging of breast tumours with computer image enhancement holds great promise but clearly requires the development of non-toxic agents, which show selective tissue localisation and absorb visible light at long wavelength (> 700 nm) so that the background absorption by haemoglobin is minimised (the optical transparency of soft tissue can be easily shown withal torch and the hand). Thus, the development of effective agents to enhance early detection rates for breast cancer would be a clear economic and quality of life benefit.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases
- medical and health sciences clinical medicine oncology breast cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.