Objective
The 20th century was the " Century of Information Technology" By common consent the 21s' century is the "a; Century of Biology" and arguably evolutionary genetics is its core technology. However, contemporary DNA sequences provide only indirect evidence of the historical processes that have formed them over long periods of time. So, in a sense, the field of molecular evolution is &pastime trapped' A revolution in our approach to evolutionary genetics has been the advent of research into ancient biomolecules. Within bimolecular science, this is one of the most innovative areas of common endeavour; an emerging European research strength. The intention of the project is to develop methods to:
* Identify DNA damage, using GC/MS with select ion monitoring. To date comparatively little is known of the types and extent of DNA damage in fossil remains. We do know that the DNA is cleaved into relatively short fragments and contains hydrolysed cytosine bases resulting in miscoding during the preliminary cycling of PCR.
* In vitro repair ancient and degraded DNA, using in-vitro Base Excision Repair (BER). BER is the major enzymatic pathway involved in the excision and subsequent repair of oxidative base damage, deprivation induced aperitif sites, and other single base insults. The outcome of this research will be to enhance the yield and quality of DNA from ancient and non-invasively collected faeces. These (unusual) samples have since proven to be one of the most robust archives of ancient DNA. The techniques developed on these samples, which exhibit remarkable DNA preservation, will then be applied to ancient human, hominid and animal bone samples from European archaeological sites dated at prehistoric and historic epochs. The recovery of ancient genetic information has great potential for the understanding of the process of evolutionary genetics first hand.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences data science data mining
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences molecular biology molecular evolution
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.