Objective
Nowadays the risk assessment of chemical pollutions is considered essential to be evaluated on measurement of the biological effects and not only on chemical analysis of environmental samples because this approach does not provide any indication of deleterious effects on living organisms. To this demand, recently the biological markers, or biomarkers which can be defined as indicator of normal physiology alteration, emerged as extremely important to monitor the pollutant impact as well as to assess the toxic effects on the environmental health. Further, new technologies mainly based on post genomic era, which combine the studies of the gene expression at level of mRNA and protein highlighted more and more questions related to the concept of the risk assessment as well as the definition of safety margin of a chemical in the environment. In this scenario, our project proposes a new method based mainly on a very sensitive technique to monitor the effects of pollutants at transcription level (mRNA) of known biomarkers. For this purpose, two biological models will be exposed to different concentrations of marine pollutants (i.e. heavy metals and organic compound) and the known biomarkers (i.e. Metallothionein, Cytochrome P450) will be analysed at level of mRNA transcription using the Real Time Quantitative PCR (Q-PCR), which allows to detect very small changes at level of mRNA expression. Our attention will be focused on two crucial concentrations of pollutants, the one that so far is considered according to the European policies; the dose without any toxic effect and it is probably that our method could already detect an effect at molecular level. The other concentration will be used to study the so called " chronic effect" of a compound. A very low dose effect will be analysed in a long-term exposure and also in this case the " sentinel" will be the biomarker mRNA expression. The researcher would like to continue this work in her home country.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences ecology ecosystems
- natural sciences earth and related environmental sciences hydrology limnology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ISPRA (VA)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.