Objective
Gonadotrophins, including Latinising hormone (LH), are key hormones regulating gonad functions. LH actions on target cells are mediated by a specific receptor, the LH receptor (LHR). A very perplexing finding has been the recent discovery of functional LHR in extragonadal tissues, e.g. in the adrenal gland which suggests some as yet unknown non-gonad functions for LH. Experimental models showed that elevated LH levels lead to LHR over-expression in the adrenals, resulting in hyperplasic and cancer. This is reminiscent of various adrenal diseases occurring concomitantly to increased LH levels in some, but not a postmenopausal women, such as hirsute, Cushing\\\'s syndrome, adrenal hyperplasic and tumours obesity and even osteoporosis. A relevant question is \\\"why do high levels of LH induce adrenalhyperfunction in some cases and not in others? \\\" To address this question, non-genetically modified mice of various genetic backgrounds will be used in order to study the occurrence of LH-dependent adrenalreponsiveness secondary to gonadectomy, which mimics the postmenopausal status. The objectives of my application are to address the molecular regulatory mechanisms involved in LH actions on adrenals. My proposal is articulated around three main axes, using multidisciplinary genomic approaches:
-First, I will determine the number of candidate genes (and if possible their identity) potentially involved in the appearance of the adrenal phenotype in mice developing the disease.
-Second, an extensive study of adrenal LHR gene expression in selected mouse strains will be performed, will search for mutations/polymorphism in the LHR promoter correlated with LHR over-expression unresponsive adrenals, and I will study the regulation of its expression. -Third, I will perform micro-array analysis to identify the genes whose LHR-induced expression leads to adrenal hyperplasic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.