The proposed project PHARMAR intends to determine several pharmaceutical agents and selected metabolites in a marine environment. As model area the Oslofjord (Norway) is chosen because known point sources (sewage treatment plants) are directly discharging into a sea area with restricted water exchange with the open sea. Thus, relatively high concentrations are expected, on one hand facilitating the analytical determination of the target analytes, on the other bearing the potential of serious risks for the local ecosystems and for the contamination of natural and aquaculture-derived seafood.
After implementation of advanced state-of-the-art analytical methodology including large-volume solid-phase extraction, high performance liquid chromatography- mass spectrometry (HPLC-MS/MS) and gas chromatography-mass spectrometry (GC-MS/MS), concentration gradients will be determined from point sources to the open sea. From the concentration data, transformation and distribution properties will be derived, applying and evaluating new concepts for the description and tracing of the environmental behaviour of contaminants. The thereby obtained property data will be of large value for subsequent environmental risk assessment of Pharmaceuticals and personal care products (PPCPs).
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