Objective
Many aspects of DNA and RNA biological functions depend on their peculiar three-dimensional structure. The complete prediction of the actual structure from their base sequence is a challenging open problem. Recently Random Matrix Theory (RMT) has been proposed as the key for a possible solution. Objectives:
-Extensive application of all well-known RMT techniques to the study, modelling, and description of the 3D- structure of RNA and DNA. -Designing and production of new numerical algorithms and computer programs for the prediction of 3D- structures of RNA and DNA, given the sequence of bases.
-Monte Carlo simulations of the matrix models for RNA and DNA. Study of thermodynamically properties, phase diagram and possible existence of glassy phases.
-Information theoretic issues and applications to combinatorial optimisation problems. Method: RMT is a classical tool of theoretical physics, which provides a natural mathematical framework for studying the interplay between fluctuating geometrical objects and their topological classification. Hence it can be used for a systematic classification and description of the complex folding of biopolymer structures according to their topological character. It gives control over their thermodynamically properties, and it leads to a number of new approximation schemes and hence to computer programs of new concepts for the prediction of the structural properties of DNA and RNA.
The work will be both theoretical and numerical. Relevance:
-The highly innovative profile of this project,
-the excellence of the host institution on RMT and applications to biophysics,
-the profound experience of the applicant with RMT and the possibility to widen his knowledge in bimolecular physics by means of a high-level Research Training. All the above fits very well with the goals of the Specific and Work Programmes. Moreover this project is relevant for several main objectives of the thematic priorities of FP6.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biophysics
- natural sciences biological sciences genetics RNA
- natural sciences physical sciences theoretical physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.