Objective
Dendrite cells (DC) are highly specialized antigen presenting cells (APC) that are critical for the initiation of T cell-dependent immune responses. The antigen uptake functions of DC are mediated by the expression of specialized surface receptors some of them belonging to the animal lection family. Recently, many lection receptors have been identified on the DC surface. On the other hand, natural killer (NK) cells also express lection receptors on their surface that controls its activity by a balance between inhibitory and activating signals. These NK receptors are close related to the DC lectinreceptors. Little is known about the functions of these lections. It is thought that most lections on DC are involved in pathogen recognition and presentation, however they may also mediate cell-cell interactions. Some lection receptors on NK recognize MHC-I, but the binding specify of most of them, or whether they can bind carbohydrates or pathogens is not known. The purpose of this activity is the functional characterization of new lections receptors expressed on dendrite and NK cells. We will define its carbohydrate specify and pathogen binding, internalisation ability and pathways, analysis of a possible role in cell-cell interactions and study of signalling events operated by these receptors. Detailed understanding of these processes will create sophisticated tools to inhibit, induce, or modulate DC and NK-specific responses in various diseases such as cancer, auto-immunity and infection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.