Objective
The development of supramolecular catalysts that rival the efficiency and selectivity of enzymes is one of the holy grails in chemistry. We believe that the dynamic combinatorial approach has the potential to become a useful new tool for catalysts discovery and synthesis.
The project will focus on the synthesis of new catalysts for hydrolysis reactions and Lewis-acic catalysed Diels-Alder reactions. As in the catalytic antibody approach, the use of a transition state analogue (TSA) as a template will induce the formation of receptors for these species that should make good catalysts. An important advantage over the catalytic antibody approach is that we have control over the recognition functionalities that will be incorporated into the prospective catalysts. In a first time, we intend to synthesise new non-polar dithiol building blocks for receptors/catalysts as well as explore hydrogen-bond donating and accepting building blocks and hydrids. We will exploit fully the versatile characteristic of L-cysteine in providing thiol functionality, homochirality and a solubilising carboxylate group in the same molecule. We also propose to extend this approach by incorporating metal centres into the catalysts. Using a TSA, which bind (weakly) to the metal centre it should be possible to select and amplify the best catalyst from dynamic combinatorial libraries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.