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Molecular mechanisms of amino acid recognition by adenylation domains of the Streptomyces coelicolor A3 (2) coelichelin nonribosomal peptide synthetase

Objective

Non-ribosomal peptide synthetases (NRPSs) are a large family of modular multienzymes that catalyse the biosynthesis of many commercially important microbial natural products. Adenylation (A) domains within each NRPS module selectively bind and activate (by reaction with ATP) the amino acids constituting the peptide. Structure based models of A-domains have recently been developed, which identify potentially important residues for amino acid recognition and facilitate the prediction of new peptide natural pr oduct structures from genome sequence data. The accuracy of these structural predictions and the role played by putative recognition residues will be investigated using the Streptomyces coelicolor A3(2) coelichelin synthetase as a model.

Call for proposal

FP6-2002-MOBILITY-5
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Funding Scheme

EIF - Marie Curie actions-Intra-European Fellowships

Coordinator

UNIVERSITY OF WARWICK
Address
Gibbet Hill Road
Coventry
United Kingdom