Objective
The described project is the first innovative demonstration of understanding the coupling between mechanical properties of cells and formation of metastases in organism on a biophysical, quantitative base. Thus, the project involves the collaborative work between different disciplines, namely biophysics (mechanical measurements), biochemistry (bioactive lipds) and medicine (clinicalconsequences).Yet, mechanical effects and its consequences for metastases formation in organisms have not beenconsidered. However, first observations made by the lab in Heidelberg in collaboration with theWeizmann Institute of Science (Israel) and the Clinical University Ulm (Germany) show convincingly that structural consequences upon cellular cytoskeleton (which is responsible for cellular mechanics)are involved in medical relevant processes. Thus, Sphingosylphosphorylcholine (SPC, a bioactivelipid) was found to cause structural changes in the cytokeration organization of epithelia cancer cells from the pancreas. Interestingly, SPC is more dominantly expressed by patients who suffer frompancreas tumours and who already distributed metastases in the body than with patients who havepancreas tumours but no formation of metastases, yet. Thus, SPC must provide a biochemical signalfor metastases formation by reorganizing the cytokeration assembly in cells. Its mechanicalconsequences for cells and for the formation of metastases from pancreas tumours is objective of thisproposal.Viscoelasticity of single cells will be determined with the single cell puller on top of an opticalmicroscope a technique established in Heidelberg. We will visualise cytoskeleton structure andmeasure viscoelasticity of Epithelial cells from the pancreas under various biochemical treatment. Thiswill enable us to define mechanical connectivity of various filament systems in cells which is supposedto play a major role in formation of metastasis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biophysics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.