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Content archived on 2024-05-29

Modulation of osteoblast function by bioactive RGD-peptides arranged in nanotemplates

Objective

The development of new methodologies in the field of material science and nanotechnology represents a useful tool to further explore and modify biomaterial design. Biocompatiblity is dependent on material-related factors, such as topography and surface chemistry, as well as cell adhesion and function. The focus of this multidisciplinary work is the creation of a system, which permits the study of bone cells adhesion and the regulation of their cellular activities. We propose to use novel chemical techniques to mimic the extracellular environment with bioactive peptides arranged into a rigid well-defined nano-template. We reason that these peptides should control cell attachment and activate integrin-dependent intracellular signaling pathways for bone cell proliferation, differentiation and death by apoptosis. The fellow will gain experience in material science, biophysical chemistry, biophysics, cell biology, and clinical research. The scientific and educational activity will be also embedded in a high quality research and education environment established at the Heidelberg University. Because of her past research experience, the candidate fits excellently to the named project where multidisciplinary skills and knowledge are needed. She will combine her abilities with the abilities of the group of Biophysical Chemistry at the University of Heidelberg, whose main focus is the control of cell adhesion by biophysics and nanotechnology. Until the end of the Marie Curie Fellowship in 2005 she will have the chance to gain enough qualifications to become an associated faculty member in an European Institute or University. The European Community is investing into a young researcher, which will have great potential to connect European research activities in future years. Thus, her will for worldwide mobility is enhancing her own scientific excellence which than will be carried forward to other young scientists and research institutions in Europe.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2002-MOBILITY-5
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

EIF - Marie Curie actions-Intra-European Fellowships

Coordinator

UNIVERSITY OF HEIDELBERG
EU contribution
No data
Address
INF 253
HEIDELBERG
Germany

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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