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A Study of the Factors Determining Penetration of Polymethyl Methacrylate Bone Cement into Trabecular Bone

Objective

Total joint replacement is a very successful operation, relieving pain and disability for approximately 1,5 million people worldwide each year. With changing demographic age distributions in the population, it is predicted that the need for such operations will increase significantly over the coming decades. Most implants use polymath methacrylate (PMMA) bone cement, which grouts the prosthesis into bone. A benchmark figure for survival to these implants is now 95% after 10 years. Even so, the number of revision operations is increasing, and themed for improved survival of the implants is very great. The predominant cause of failure is aseptic loosening, due to an inflammatory reaction at the interface between the cement of bone. However, data from roentgen stereophotogrammetric analysis (RSA) from the host laboratory and others indicates that early migration of the prosthesis is predictive of failure many years later. These observations suggest that failure of the initial fixation contributes to later failure. Pressurisation of cement is known to increase penetration of cement into orbicular bone and to provide good initial fixation. However, even at an anatomical site such as the femur, in which pressurisation is relatively easy to achieve, rapid variations in the viscosity of the cement during delivery can make it difficult to predict adequate cement penetration into bone. At other sites, such as the acetabulum (pelvis) and proximal tibia, it can be difficult to achieve significant pressurisation. The scientific proposal is, therefore, that a detailed study of the viscosity of bone cement, coupled with identification of specific surgical problems at particular anatomical locations, will significantly enhance initial fixation of implants. This study will investigate current commercially available cements, as well as novel cements being developed within the department that contain iodine-based contrast agents. Demographic changes are leading to a #

Call for proposal

FP6-2002-MOBILITY-5
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Funding Scheme

EIF - Marie Curie actions-Intra-European Fellowships

Coordinator

LUNDS UNIVERSITET
Address
Paradisgatan 5C
Lund
Sweden