Objective
Total joint replacement is a very successful operation, relieving pain and disability for approximately 1,5 million people worldwide each year. With changing demographic age distributions in the population, it is predicted that the need for such operations will increase significantly over the coming decades. Most implants use polymath methacrylate (PMMA) bone cement, which grouts the prosthesis into bone. A benchmark figure for survival to these implants is now 95% after 10 years. Even so, the number of revision operations is increasing, and themed for improved survival of the implants is very great. The predominant cause of failure is aseptic loosening, due to an inflammatory reaction at the interface between the cement of bone. However, data from roentgen stereophotogrammetric analysis (RSA) from the host laboratory and others indicates that early migration of the prosthesis is predictive of failure many years later. These observations suggest that failure of the initial fixation contributes to later failure. Pressurisation of cement is known to increase penetration of cement into orbicular bone and to provide good initial fixation. However, even at an anatomical site such as the femur, in which pressurisation is relatively easy to achieve, rapid variations in the viscosity of the cement during delivery can make it difficult to predict adequate cement penetration into bone. At other sites, such as the acetabulum (pelvis) and proximal tibia, it can be difficult to achieve significant pressurisation. The scientific proposal is, therefore, that a detailed study of the viscosity of bone cement, coupled with identification of specific surgical problems at particular anatomical locations, will significantly enhance initial fixation of implants. This study will investigate current commercially available cements, as well as novel cements being developed within the department that contain iodine-based contrast agents. Demographic changes are leading to a #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- engineering and technology materials engineering amorphous solids organic amorphous solids
- natural sciences chemical sciences inorganic chemistry metalloids
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.