Objective
A striking feature of a neuron is its dendrite tree. Among other things, dendrites convey information from synaptic contacts with other cells. Learning and memory rethought to be mediated by the activity-dependent modification of synaptic connective strengths, a notion termed synaptic plasticity. Rules for plasticity describe the activity that modifies the strength of a synaptic connection; properties such as diameter and length of the dendrite branch on which a synapse is located will influence this activity. Hence, synaptic plasticity rules depend on dendrite properties as well as on synapses location in the dendrite tree. I propose to examine the location dependence of plasticity rules in cortical layer 5pyramidal neurons, which have apical and basal dendrite regions with distinct synaptic inputs. I will address how the different biophysical properties of these regions underlie synaptic plasticity with the ultimate goal of deriving a detailed computer model of dendrite biophysics and its role in plasticity. I have previously studied plasticity rules in one location of layer 5 neurons using methods that have limited me to describing plasticity, without addressing underlying mechanisms in great detail. In Dr. Hausers lab, I will learn several advanced biophysical methods that I will use towards my goal of understanding synapticplasticity.The biophysical methods I will learn in Dr. Hausers lab will add to my scientific breadth by complementing my expertise in electro physiology and molecular biology. This will help me when I ultimately have my own lab. Finally, being Swedish, I believe Will benefit from learning more about science in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology
- natural sciences biological sciences biophysics
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.