Objective A striking feature of a neuron is its dendrite tree. Among other things, dendrites convey information from synaptic contacts with other cells. Learning and memory rethought to be mediated by the activity-dependent modification of synaptic connective strengths, a notion termed synaptic plasticity. Rules for plasticity describe the activity that modifies the strength of a synaptic connection; properties such as diameter and length of the dendrite branch on which a synapse is located will influence this activity. Hence, synaptic plasticity rules depend on dendrite properties as well as on synapses location in the dendrite tree. I propose to examine the location dependence of plasticity rules in cortical layer 5pyramidal neurons, which have apical and basal dendrite regions with distinct synaptic inputs. I will address how the different biophysical properties of these regions underlie synaptic plasticity with the ultimate goal of deriving a detailed computer model of dendrite biophysics and its role in plasticity. I have previously studied plasticity rules in one location of layer 5 neurons using methods that have limited me to describing plasticity, without addressing underlying mechanisms in great detail. In Dr. Hausers lab, I will learn several advanced biophysical methods that I will use towards my goal of understanding synapticplasticity.The biophysical methods I will learn in Dr. Hausers lab will add to my scientific breadth by complementing my expertise in electro physiology and molecular biology. This will help me when I ultimately have my own lab. Finally, being Swedish, I believe Will benefit from learning more about science in Europe. Fields of science medical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesbiophysicsnatural sciencesbiological sciencesmolecular biology Keywords biophysics calcium imaging electrophysiology synaptic plasticity theoretical neuroscience Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2002-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator UNIVERSITY COLLEGE LONDON Address Gower street London United Kingdom See on map EU contribution € 0,00
