Objective
Candid alb cans are able to respond to environmental changes by inducing a distinct morphological program, which is related to the ability to infect mammalian hosts. Although some of the signal transudation pathwaysinvolveld in this response are known, it is not clear how the environmental signals are sensed and transmitted to these transudation cascades. The two most important signal transudation pathways involved in the transition from yeast-like cells to hyphen cells are the camp-PKA and the Amidogen Activated protein kinase (MARK) pathways. In Saccharomyces cerevisiae the camp-PKA pathway is triggered through activation by glucose or sucrose of the G-protein coupled receptor Gpr1 and the M APK pathway is triggered by the binding of pheromones to the pheromone G-protein coupled receptor. A C. alb cans Gpr1 homologue exists in the genome databases and it shows extensive homology to the S. cerevisiae Gpr1 protein. In the host laboratory the Capri gene was recently deleted and the resulting deleted strain shows defect in hyphen formation on some solid hyphal-inducingmedia. The transition from yeast cells to hyphen cells is believed to be associated to virulence of this otherwise opportunistic pathogenic organism. The proposed project aims to characterize the C. alb cans Gpr1 receptor in more detail. We will identify the ligand by which this receptor is activated and we will determine the ligandbinding sites of the receptor. To achieve this we will use SCAM analysis (Substituted Cytokine Accessibility method), in which binding of a sulfhydryl-reactive agent in an aqueous environment is used to block access of Thailand to the receptor. The research will also focus on the characterization of the signal transudation pathway thats being activated by interaction between the legend and the Capri receptor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ZWIJNAARDE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.