Objective
Arial fibrillation is the most common chronic arrhythmia afflicting 4% of the population over the age of 60 years. With aging of the population this incidence is going to increase. Serious complications such as emboli stroke and cerebral haemorrhage (as patients need to beanticoagulated) a high morbidity and mortality are associated with atria fibrillation with greatsocio-economic implications. Until today, however, there is no effective treatment of the arrhythmia. Chronic atria fibrillation grows more resistant to pharmacological and electricalcardioversion the longer it persists. In recent years it has been elucidated that during the time course after the initiation of the arrhythmia a complex remodelling of the atria takes place, which involves the electrical, contractile and structural properties. Electrical remodelling leads to a reduction in the atria effective refractory period and a shortening of the action potential. Contractile remodelling is characterized by a loss of 70% of atria contractile function leading to thrombus formation in the atria with the risk of emboli stroke if the thrombus dislodges. It has been shown that alteration in intracellular Ca2+ homeostasis and Ca2+ handling properties play a major role in the remodelling process. During atria fibrillation intracellular Ca2+ and Na+concentrations increase. Although major insights into the path physiology of atria fibrillation on the cellular level have been gained the actual changes in intracellular ion concentrations have never been directly measured. Changes in intracellular calcium handling strongly interact with intracellular Na+ and H+ homeostasis. Therefore this project addresses the changes in alterations in intracellular ion concentrations (Ca2+, Na+ and H+) and ion handling properties in two established animal models of atria fibrillation as well as in human tissue of patients with chronic atria fibrillation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- social sciences sociology demography mortality
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine neurology stroke
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MAASTRICHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.