Objective
The turnover and remodelling of extra cellular matrix (ECM) is an important feature after vascular injury in noontime formation and remodelling of the injured vessels. Collagen is the major ECM protein and can only be degraded by the matrix metalloproteases (Mumps). Broad spectrum MMP-inhibitors can prevent arterial shrinkage and noontime formation but suffer from severe side effects after prolonged administration in humans. To find a specific target(s) for intervention, we have to understand how turnover of collagen is regulated. Collagen degradation is dependent on the action of several matrix metalloproteinases and MMP activity is regulated at multiple levels. The expression ofMT1-MMP, MMP2 and MMP-9 are early unregulated in time after vascular injury. Although, the activation of MT-1MMP(MMP2) takes place on the cell surface the compartmental basis for integrating the Tran membrane signalling underlying the MMP2 activation cascade into cells remains to be established. MMP2, MT1-MMP and TIMP-2 are co-localized with Caveolin-1, a major constituent of theCaveolae. The cellular functions of Cavalla are not yet fully understood. Recently, the study of sub cellular distribution of carboxyl-terminally green fluorescent protein GFP-tagged Cav-1 (Cav-1-GFP) revealed that this protein has high mobility within cells. Cav-1 can be found at the cell surface, associated with Googly complex and present in alveolar vesicles.
Cav-1,moves bi-directional between the cell surface and cell interior. Several reports have shown that certain viruses, lipid-bound toxins and certain glycosylphosphosphatidylinositol (GPI)- linked proteins enter cells and are sorted to different sub cellular locations bypassing endoscopes using a recently described organelle (termed the \"Cave some\"). This organelle has been visualized by electronic microscopy and it lacks markers for early-endoscopes, liposomes, ER or Googly complex but are rich in caveolin-1.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.