Objective
The post-genomic era offers exciting new opportunities for vaccine research, which are expected to shorten the time of vaccine. The complete knowledge of the gene repertoire of a given pathogen can become the launching platform for three approaches aiming at the identification of new vaccine candidates. According to one strategy, named reverse vaccinology, genes are selected in silicon utilizing algorithms that can predict genes encoding for secreted and surface-associated proteins and virulence factors. These proteins are considered the most relevant for the induction of a protective immune response. The second approach is aimed at the identification of invasion and virulence-associated antigens and make use of several new technologies including in vivo expression technology, signature-tagged autogenesis and DNA micro array technology. In the third approach, surface exposed antigens are selected experimentally through the characterization of membrane proteins fraction usingproteomics techniques such as two dimensional gel electrophoresis, or two dimensional chromatography and mass spectrometry. The specific area of research in which the proposal refers is to identify a set of potential vaccine candidates against Streptococcus progenies (group A streptococcus, GAS) using a proteomics approach. This approach will complement a reverse vaccinology approach, and a DNA micro array technology based approach already initiated in the laboratory. A range of illness and disease has been associated with GAS infection including pharyngitis, impetigo and scarlet fever. More invasive infection can because by GAS including toxic shock syndrome and narcotising fascistic, as well as rheumatic fever and rheumatic heart disease. GAS infections have increased in frequency and severity in the last decade in the United States and Europe, and they are a major problem in developing countries and indigenous population worldwide, particularly in Australia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SIENNA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.