Objective
Chronic pain undermines the health and welfare of millions of EU citizens and carries enormous financial costs. Individual variability in the burden of pain has traditionally been attributed to psychosocial factors. However, new data indicate that there is an important heritable predisposition to pain, particularly to the development of chronic pain after neural injury (neuropathic pain). Pain susceptibility genes are intrinsically hard to detect in human lineages and populations. We propose the alternative approach of exploiting new rodent models of neuropathy to uncover pain susceptibility loci and associated neurobiological processes, using inbred mouse strains that show high versus low pain phenotype. Linkage analysis and positional cloning, together with expression arrays and a variety electrophysiological and neurochemical methods applied to primary sensory neurons, will be used to identify the biological causes of contrasting pain phenotype. The strategy is to identify genetic and cellular variables that co-vary with pain phenotype across strains. With mouse candidate genes in hand, identification of the human orthologs is feasible. We stress that our project does not aim to find genes that affect susceptibility to specific disease entities that may be painful. Rather, we focus on genes and processes that determine the amount of pain felt by an individual in the presence of a specific disease state or degree of tissue injury. That is, we will investigate pain susceptibility genes rather than disease susceptibility genes. Such genes, and the neural processes with which they are associated, are expected to affect pain intensity irrespective of the proximate cause of the neural damage: trauma, surgery, neoplasm, infection or disease. Results will facilitate the development of novel prognostic, diagnostic and treatment options for chronic pain sufferers, with benefits also for their families, employers and European economies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences biological sciences biochemistry biomolecules
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.