Objective
In the pathways of gene expression, by which information is transferred from DNA to end-up with a functional protein, the first regulated and in most cases rate-limiting step is the process of transcription. Despite the detailed picture that is emerging about the composition of the RNA polymerase-ll machinery, a great number of conceptual as well as mechanistic questions are still needed to be resolved before we can attain a complete picture of the principles employed by living organisms to control this process. One of the main gaps in our knowledge is the limited insight we have on transcription regulation in the nuclear environment. The dynamic association of RNA polymerase-ll with general transcription factor complexes within the nucleus, the trafficking of the components between nuclear structures, the forces governing complex-complex interactions and the pacemaker of their intrinsic dynamics at the DNA-protein surfaces of the genes is poorly understood.
The general goal of the network is to obtain a comprehensive knowledge on the mechanism of regulation of model genes during cell differentiation, cell proliferation and signal transduction. The network will undertake concerted efforts to develop and apply fluorescent imaging techniques, coupled with genetic, proteomic and conventional molecular and cell biology approaches to study the molecular characteristics and functions of individual multiprotein complexes and their dynamic interplay in the context of unique chromatin structures in living cells.Successful execution of the project is expected to result in:
i. New knowledge on the in-situ dynamics of RNA polymerase-ll machinery,
ii. New knowledge on the molecular mechanism of transcription regulation that leads to pathway-specific gene expression programs,
iii. Development of new technologies and research tools.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics topology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HERAKLION
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.