Objective
The aim of this proposal is to explore the role of non-coding genetic information by identifying novel non-coding RNA genes (ncRNAs) and analyse their mechanisms of action and impact on cell differentiation and disease. We will concentrate on ncRNAs acting on post-transcriptional processes and bring together European laboratories with expertise in RNA biology, bioinformatics/prediction software and industrial exploitation of genomes. Using multidisciplinary functional genomic approaches, we will address a hitherto under-investigated topic and generate highly novel information on gene content and function in Arabidopsis thaliana, Caenorhibditis elegans, mouse and human. We will mine databases and use a large-scale genomic approach (RNomics) to search for new ncRNAs in diverse organisms and for their human orthologues. We will construct ncRNAs gene-chips and study their expression in different genetic backgrounds and cellular or developmental conditions, including cancer cell lines. Using multidisciplinary approaches, we will unravel new regulatory processes and mechanisms involving ncRNAs, highly informative by their generality and/or their direct relation to human diseases, We will study the composition of protein complexes containing the ncRNAs, their mode of action and impact. Altering ncRNA activity will be evaluated through transcriptome to identify potential targets in RNA-mediated developmental rocesses. The knowledge generated by this project is urgently required to correctly exploit the huge amount of sequence data available and to better integrate post-genomic research into biomédical and biotechnological approaches. This project will give European biotechnology industries a critical leading edge to exploit the full potential of genome information to underpin applications to human health. The proposed work will also provide knowledge to develop technologies and therapeutic tools based on RNA molecules.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.