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Genomics and Blood Substitutes for 21st Century Europe

Objective

Blood transfusion is universally practised in all European countries. Blood is a biologic material that has the potential to transmit diseases (e.g. HIV and, perhaps, vCJD). European citizens are becoming increasingly concerned about blood safety, despite improved screening and processing. Such concerns are making people reluctant to donate blood or receive it through transfusions. Safe, effective and commercially viable blood substitutes will overcome this problem.

The EuroBloodSubstitutes Project brings together a multi-disciplinary, mixed gender team of experienced academic scientists, clinicians, industrialists and transfusion specialists to develop an integrated technological platform for generating blood substitutes for critical blood components, in particular oxygen carriers (novel prototype haem proteins), that will, longer-term, benefit all European citizens. The Project has a fundamental focus on novel, genomic-based approaches, involving the use of cell factories, for developing and optimising strategies for the efficient generation, modification, purification, biochemical and biophysical characterisation and physiological evaluation of prototype native, modified and variant haemoglobins for improved formulations of blood substitutes to replace some blood uses.

The project will be informed by consultation and dialogue with lay (i.e. the public, patient groups), professional (clinical preservers and providers) and commercial (especially SME) stakeholders. The EuroBloodSubstitutes Project is directly relevant to the LifeSciHealth Thematic Priority of the 6th Framework Programme because it provides a baseline for integrating post-genomic research into biomedicaland biotechnological areas (generating prototype critical blood substitute components) that aims to stengthen European commerce (through blood substitute manufacture) and improve the future quality of life (through blood substitute use) for European people.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Address
University Park
Nottingham
United Kingdom

Participants (12)

UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA"
Italy
Address
Piazzale Aldo Moro 5
Roma
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5C
Lund
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milano
UNIVERSITA DEGLI STUDI DI PARMA
Italy
Address
Via Universita 12
Parma
UNIVERSITY OF ESSEX
United Kingdom
Address
Wivenhoe Park
Colchester
SEMMELWEIS EGYETEM
Hungary
Address
Uelloi Ut 26
Budapest
DANMARKS TEKNISKE UNIVERSITET
Denmark
Address
Anker Engelundsvej 1, Bygning 101A
Lyngby
ALLIGATOR BIOSCIENCE AB
Sweden
Address
Scheelevagen, 19A
Lund
LCC ENGINEERING & TRADING GMBH
Switzerland
Address
Steinbruchstrasse 43
Egerkingen
COMMON SERVICES AGENCY
United Kingdom
Address
Trinity Park House, South Trinity Road
Edinburgh
STICHTING SANQUIN BLOEDVOORZIENING
Netherlands
Address

An Amsterdam
UNIVERSITE HENRI POINCARE NANCY 1
France
Address
Rue Lionnois 24-30
Nancy