Objective
The project through collaborative studies will define prognostic markers and new therapeutic targets in the Ewing's sarcoma family of tumours (ESFT) to provide rigorous scientific justifications for the development of clinical trials for this rare disease, which is manifested for the most part in children. The main objective of this project is to evaluate the prognostic relevance of selected markers (EWS/FLI-1, secondary genetic alterations, CD99, IGF-IR, NOVH, erbB-2 and TTF1) and the effectiveness of therapeutic approaches targeting some of these molecules. The prognostic value of these markers will be evaluated in retrospective and prospective series of ESFT patients treated across the participating centres. Through statistical analysis, we will verify which factors have the highest prognostic impact in ESFT patients, in terms of overall survival, disease progression, and chemosensitivity. In order to provide the necessary rationale for the forthcoming application of new therapies, the preclinical effectiveness of new drugs (Herceptin) and strategies targeting molecules (CD99, IGF-IR, EWS/FLI1) found to be critical for ESFT will be evaluated. Another major goal of the project is the construction of ESFT c- DNA microarrays and tissue arrays, which will be used for the analysis of different hystological subtypes of ESFT, primary and metastatic tumours and poor and good responders to chemotherapy. Therefore, the expected results are: 1) identification of prognostic factors in ESFT; 2) definition of patient selection criteria 3) creation of new therapeutic bullets against ESFT; 4) identification of new therapies; 5) creation of new tools for the diagnosis and screening of high-risk groups. This will lead to: 1) the definition of forthcoming risk-adapted strategies and targeted molecular treatments to be advantageously combined with established therapies; 2) improved quality of life and survival for ESFT patients...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BOLOGNA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.