Objective The objectives of this proposal are to identify genes, proteins and molecular pathways involved in regulating the metastasis of breast cancer to specific organs. To achieve these objectives we will use a combination of gene expression profiling, bioinformatic analysis, histology of human female breast cancer samples, genetic manipulation of transplantable tumour cells and transgenic mouse technology. In addition to finding new genes, we aim to analyse to what extent genes already known to play a role in breast cancer metastasis specify which organs breast tumours metastasise to. We will also establish how the currently known genes that are associated with breast cancer dissemination and the new ones we identify fit together into pathways that regulate organ- specific metastasis. These findings will be coupled with the analysis of clinical trials that participants in this consortium are involved in. Further deliverables include the development of improved animal models for the study of breast cancer metastasis, and the development of diagnostic methods for determining whether primary tumours already have metastatic potential. Together, the work packages in this proposal will establish a pipeline of activities that unite basic research into the organ-specific metastasis of breast cancer with target validation and clinical application. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesbiological scienceshistology Keywords animal models breast cancer gene expression profiling metastasis microarray models signal transduction Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.2.0-7 - Molecular mechanisms involved in organ-specific metastatic growth processes in breast cancer Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator FORSCHUNGSZENTRUM KARLSRUHE GMBH EU contribution No data Address Weberstr. 5 KARLSRUHE Germany See on map Links Website Opens in new window Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY Belgium EU contribution No data Address Rijvisschestraat 120 GENT (ZWIJNAARDE) See on map Links Website Opens in new window Total cost No data UNIVERSITY OF BASEL Switzerland EU contribution No data Address Petersgraben 35 BASEL See on map Links Website Opens in new window Total cost No data DANISH CANCER SOCIETY, INSTITUTE OF CANCER BIOLOGY Denmark EU contribution No data Address Strandboulevarden 49 COPENHAGEN See on map Links Website Opens in new window Total cost No data INSTITUT CURIE France EU contribution No data Address 26 RUE D'ULM PARIS See on map Links Website Opens in new window Total cost No data G2M CANCER DRUGS AG Germany EU contribution No data Address Paul-Ehrlich-Strasse 42-44 FRANKFURT AM MAIN See on map Links Website Opens in new window Total cost No data UNIVERSITÉ DE LIÈGE Belgium EU contribution No data Address Place du XX Août, 7 LIÈGE See on map Links Website Opens in new window Total cost No data THE NETHERLANDS CANCER INSTITUTE Netherlands EU contribution No data Address Plesmanlaan 121 AMSTERDAM See on map Links Website Opens in new window Total cost No data CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS Germany EU contribution No data Address Paul-Ehrlich-Str. 42-44 700251 FRANKFURT AM MAIN See on map Links Website Opens in new window Total cost No data FONDAZIONE TELETHON Italy EU contribution No data Address Via G. Saliceto, 5 ROME See on map Links Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERQUE SCIENTIFIQUE France EU contribution No data Address 3, rue Michel-Ange PARIS See on map Links Website Opens in new window Total cost No data CEINGE BIOTECNOLOGIE AVANZATE S.C.A.R.L. Italy EU contribution No data Address Via Comunale Margherita 482 NAPLES See on map Links Website Opens in new window Total cost No data LEIDS UNIVERSITAIR MEDISCH CENTRUM Netherlands EU contribution No data Address Wassenaarseweg 72 9503 LEIDEN See on map Links Website Opens in new window Total cost No data CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN, CAMPUS BUCH Germany EU contribution No data Address Lindenberger Weg 80 BERLIN See on map Links Website Opens in new window Total cost No data JOHANNES GUTENBERG-UNIVERSITÄT MAINZ Germany EU contribution No data Address Saarstr. 21 MAINZ See on map Links Website Opens in new window Total cost No data