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Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network

Objective

The establishment of non-invasive markers for prenatal diagnosis is an important research goal. Current invasive procedures have a significant risk of induced abortion (1-2%) or maternal injury and considerable discomfort and psychological distress. Currently around 5% of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities . In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found to be carriers of the risk of having an affected child. The transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells (1/105 - 1/107), substantial progress has been made by individual research groups in Europe.

As these results are all based on small scale independent studies, there is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis. The recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Funding Scheme

NoE - Network of Excellence

Coordinator

THE UNIVERSITY OF WARWICK
Address
Gibbet Hill Road
Coventry
United Kingdom

Participants (48)

UNIVERSITY OF BASEL
Switzerland
Address
Petersgraben 35
Basel
UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL
United Kingdom
Address
Frenchay Campus, Coldharbour Lane
Bristol
OXFORD BROOKES UNIVERSITY
United Kingdom
Address
Gipsy Lane, Headington
Oxford
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
UNIVERSITAT ROVIRA I VIRGILI
Spain
Address
C/de L'escorxador S/n
Tarragona
MEDIZINISCHE UNIVERSITAET GRAZ (MEDICAL UNIVERSITY GRAZ)
Austria
Address
Auenbruggerplatz 2
Graz
SANQUIN BLOOD SUPPLY FOUNDATION
Netherlands
Address
Plesmanlaan 125
Amsterdam
CHARLES UNIVERSITY PRAGUE, 2ND MEDICAL FACULTY
Czechia
Address
V Úvalu 84
Prague 5
METASYSTEMS HARD UND SOFTWARE GMBH
Germany
Address
Robert-bosch-str. 6
Altlussheim
IMSTAR SA
France
Address
60 Rue Notre Dame Des Champs
Paris
HELSINKI UNIVERSITY
Finland
Address
Yliopistonkatu 4
Helsinki
ESTONIAN BIOCENTRE
Estonia
Address
Riia 23 Str.
Tartu
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
Address
Kings College
Aberdeen
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan
UNIVERSITY MEDICAL CENTER NIJMEGEN
Netherlands
Address
Geert Grooteplein 10
Nijmegen
AMERICAN HOSPITAL OF PARIS
France
Address
63 Bd Victor Hugo
Neuilly-sur-seine
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
6, Christou Lada Str
Athens
CHAIM SHEBA MEDICAL CENTER
Israel
Address
Sheba Medical Center
Tel-hashomer
HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS
Spain
Address
Celestino Villamil S/n
Oviedo
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
South Kensington Campus
London
THE CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS
Cyprus
Address
International Airport Avenue, 6
Nicosia
UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndall Avenue, Bs8 1Th
Bristol
UNIVERSITY OF ZURICH
Switzerland
Address
Raemistrasse 71
Zurich
UNIVERSITA' DEGLI STUDI DI PERUGIA'
Italy
Address
Piazza Universita', 1'
Perugia
INSTITUT NATIONAL DE SANTE ET FECHERCHE MEDICALE
France
Address
Rue Tolbiac, 101
Paris
STATISTIK DR. M. BUSER
Switzerland
Address
Private:doernliweg 31
Riehen
GENETIC INTEREST GROUP
United Kingdom
Address
Leroy House 436 Essex Road
London
THE OPEN UNIVERSITY CENTRE FOR EDUCATION IN MEDICINE
United Kingdom
Address
Walton Hall
Milton Keynes
ZHONGSHAN MEDICAL COLLEGE, SUN YAT-SEN UNIVERSITY
China
Address
74 Zhongshan Road Ii
Guangzhou
NHS BLOOD AND TRANSPLANT
United Kingdom
Address
Oak House, Reeds Crescent
Watford
LUND UNIVERSITY HOSPITAL BLOOD CENTRE
Sweden
Address
Getingevägen
Lund
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
LEON KOZMINSKI ACADEMY OF ENTREPRENEURSHIP AND MANAGEMENT
Poland
Address
Jagiellonska 59
Warszaw
ECOLE PRATIQUE DES HAUTES ETUDES
France
Address
45-47, Rue Des Ecoles
Paris
CARL ZEISS MICROIMAGING GMBH
Germany
Address
Kistlerhofstraße 75
Munich
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA DIPARTIMENTO DI MEDICINA INTERNA CARDIOANGIOLOGIA EPATOLOGIA
Italy
Address
Via Massarenti, 9
Bologna
KAROLINSKA INSTITUTET
Sweden
Address
-
Stockholm
MICROBIOLOGY RESEARCH CENTRE HOLLAND
Netherlands
Address
Hudsonstraat 68 Hs
Amsterdam
THE RARE CHROMOSOME DISORDER SUPPORT GROUP
United Kingdom
Address
-
Caterham
STATENS SERUM INSTITUT
Denmark
Address
Artillerivej, 5
Copenhagen
GENERAL LAB S.A.
Spain
Address
C/ Londres 45
Barcelona
VU UNIVERSITY MEDICAL CENTER
Netherlands
Address
De Boelelaan 1117
Amsterdam
WAYPOINT SYSTEMS LTD
United Kingdom
Address
2 Park Avenue, New Street
Shrewsbury, Shropshire
CNR-CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzala Aldo Moro 7
Rome
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
India
Address
Ansari Nagar
New Delhi
UNIVERSITY OF COPENHAGEN
Denmark
Address
Blegdamsvej 3
Copenhagen
UNIVERSITÀ DEGLI STUDI DI TRENTO
Italy
Address
Via Belerzani 12, 38100
Trento
UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS
Germany
Address
Robert-koch-strasse 40
Goettingen