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Coordination Action on the Aetiology, pathology and prediction of type 1 diabetes in Europe

Objective

Type 1 diabetes mellitus (T1DM) imposes a heavy burden of morbidity and premature death on more than 2 million inhabitants in Europe. To identify new targets for prevention, diagnosis and treatment of type 1 diabetes mellitus (T1DM) greater understanding of the aetiology and pathology of T1DM is crucial. This requires the elucidation of the cellular and molecular mechanisms responsible for T1DM through bringing together leading European centres of expertise in the field of clinical and experimental T1DM research. The capabilities of the European groups participating in this Coordination Action (CA) provide the required technical skills and innovative advances. European diabetes research expertise in T1DM as assembled in this CA proposal will enable the coordination of RTD projects, which are already in receipt of funding for the research part. The research topics to be coordinated in this CA deal with a) molecular mechanisms of beta cell death and signalling pathways of apoptosis in T1DM b) the impact of environmental factors upon the genetically based regulation and progression of T1DM c) the use of established and new animal models to unravel the molecular mechanisms of the aetiology and pathology of T1DM d) the role of the cellular immune system in the pathogenesis of T1DM. The financial support for this CA will allow the running of the coordination activities. The workplan comprises eight workpackages (WPs). Four WPs deal with the specific CA co-ordination activities, directed towards the four major scientific objectives of the research to be coordinated. Three WPs deal with the overall CA co-ordination activities and one WP comprises the CA management activities. This will make it possible to detect the underlying causes of T1DM with the aim of identifying targets for prevention, diagnosis and treatment.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

CA - Coordination action

Coordinator

HANNOVER MEDICAL SCHOOL
Address
Carl-neuberg-str. 1
Hannover
Germany

Participants (26)

ASTON UNIVERSITY
United Kingdom
Address
Aston Triangle
Birmingham
UNIVERSITY OF BRIGHTON
United Kingdom
Address
Moulsecoomb
Brighton
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina, 60
Milan
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
F.d. Roosevelt 50
Bruxelles
UNIVERSITY OF ULSTER
United Kingdom
Address

Coleraine
THE UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndall Avenue
Bristol
HOSPITAL CLINIC PROVINCIAL DE BARCELONA
Spain
Address
Calle Villarroel 170
Barcelona
KING'S COLLEGE LONDON'
United Kingdom
KAROLINSKA INSTITUTET
Sweden
Address

Stockholm
LILLY RESEARCH LABORATORIES
Germany
Address
Essener Str. 93
Hamburg
STENO DIABETES CENTER
Denmark
Address
Niels Steensens Vej 2
Gentofte
UNIVERSITY OF PISA
Italy
Address
Via Paradisa 2
Pisa
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Herestraat 49
Leuven
HOSPITAL UNIVERSITARI DE BELLVITGE
Spain
Address
Feixa Llarga S/n
L'hospitalet De Llobregat. Barcelona'
THE UNIVERSITY OF EXETER
United Kingdom
Address
Northcote House, The Queen's Drive
Exeter, Devon
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Address
Wilhelmstr. 7
Tuebingen
UNIVERSITY COLLEGE DUBLIN
Ireland
Address
Belfield
Dublin 4
UNIVERSITY OF HELSINKI
Finland
Address
Yliopistonkatu 4
University Of Helsinki, Helsinki
LEIDEN UNIVERSITY MEDICAL CENTER
Netherlands
Address
Albinusdreef 2
Rc Leiden
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Mannerheimintie 166
Helsinki
ERNST-MORITZ-ARNDT-UNIVERSITY
Germany
Address
Klinikum/sauerbruchstrasse
Greifswald
UPPSALA UNIVERSITY
Sweden
Address
Husargatan 3
Uppsala
CENTRE EUROPÉEN D'ÉTUDE DU DIABÈTE'
France
Address
Boulevard René Leriche
Strasbourg
FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE
Spain
Address
Gran Vía S/n Km. 2,7
L´hospitalet De Llobregat ( Barcelona )
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALA
France
Address
251, Rue Du Faubourg Saint Martin
Paris
UNIVERSITÀ DEGLI STUDI DI SIENA
Italy
Address
Banchi Di Sotto, 55
Siena