Objective Type 1 diabetes mellitus (T1DM) imposes a heavy burden of morbidity and premature death on more than 2 million inhabitants in Europe. To identify new targets for prevention, diagnosis and treatment of type 1 diabetes mellitus (T1DM) greater understanding of the aetiology and pathology of T1DM is crucial. This requires the elucidation of the cellular and molecular mechanisms responsible for T1DM through bringing together leading European centres of expertise in the field of clinical and experimental T1DM research. The capabilities of the European groups participating in this Coordination Action (CA) provide the required technical skills and innovative advances. European diabetes research expertise in T1DM as assembled in this CA proposal will enable the coordination of RTD projects, which are already in receipt of funding for the research part. The research topics to be coordinated in this CA deal with a) molecular mechanisms of beta cell death and signalling pathways of apoptosis in T1DM b) the impact of environmental factors upon the genetically based regulation and progression of T1DM c) the use of established and new animal models to unravel the molecular mechanisms of the aetiology and pathology of T1DM d) the role of the cellular immune system in the pathogenesis of T1DM. The financial support for this CA will allow the running of the coordination activities. The workplan comprises eight workpackages (WPs). Four WPs deal with the specific CA co-ordination activities, directed towards the four major scientific objectives of the research to be coordinated. Three WPs deal with the overall CA co-ordination activities and one WP comprises the CA management activities. This will make it possible to detect the underlying causes of T1DM with the aim of identifying targets for prevention, diagnosis and treatment. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepathology Keywords Type 1 diabetes animal models apoptosis pancreatic beta cell Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LIFESCIHEALTH-2.1.1 - Combating cardiovascular diseases, diabetes, and rare diseases LSH-2002-2.1.1-8 - Aetiology, pathology and prediction of type 1 diabetes in Europe Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme CA - Coordination action Coordinator HANNOVER MEDICAL SCHOOL Address Carl-neuberg-str. 1 Hannover Germany See on map Links Website Opens in new window EU contribution € 0,00 Participants (26) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASTON UNIVERSITY United Kingdom EU contribution € 0,00 Address Aston triangle Birmingham See on map Links Website Opens in new window UNIVERSITY OF BRIGHTON United Kingdom EU contribution € 0,00 Address Moulsecoomb Brighton See on map Links Website Opens in new window FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution € 0,00 Address Via olgettina, 60 Milan See on map Links Website Opens in new window UNIVERSITE LIBRE DE BRUXELLES Belgium EU contribution € 0,00 Address F.d. roosevelt 50 Bruxelles See on map Links Website Opens in new window UNIVERSITY OF ULSTER United Kingdom EU contribution € 0,00 Address Coleraine See on map Links Website Opens in new window THE UNIVERSITY OF BRISTOL United Kingdom EU contribution € 0,00 Address Senate house, tyndall avenue Bristol See on map Links Website Opens in new window HOSPITAL CLINIC PROVINCIAL DE BARCELONA Spain EU contribution € 0,00 Address Calle villarroel 170 Barcelona See on map Links Website Opens in new window KING'S COLLEGE LONDON' United Kingdom EU contribution € 0,00 Address London See on map Links Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 0,00 Address Stockholm See on map Links Website Opens in new window LILLY RESEARCH LABORATORIES Germany EU contribution € 0,00 Address Essener str. 93 Hamburg See on map Links Website Opens in new window STENO DIABETES CENTER Denmark EU contribution € 0,00 Address Niels steensens vej 2 Gentofte See on map Links Website Opens in new window UNIVERSITY OF PISA Italy EU contribution € 0,00 Address Via paradisa 2 Pisa See on map Links Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 0,00 Address Herestraat 49 Leuven See on map Links Website Opens in new window HOSPITAL UNIVERSITARI DE BELLVITGE Spain EU contribution € 0,00 Address Feixa llarga s/n L'hospitalet de llobregat. barcelona' See on map Links Website Opens in new window THE UNIVERSITY OF EXETER United Kingdom EU contribution € 0,00 Address Northcote house, the queen's drive Exeter, devon See on map Links Website Opens in new window EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 0,00 Address Wilhelmstr. 7 Tuebingen See on map Links Website Opens in new window UNIVERSITY COLLEGE DUBLIN Ireland EU contribution € 0,00 Address Belfield Dublin 4 See on map Links Website Opens in new window UNIVERSITY OF HELSINKI Finland EU contribution € 0,00 Address Yliopistonkatu 4 University of helsinki, helsinki See on map Links Website Opens in new window LEIDEN UNIVERSITY MEDICAL CENTER Netherlands EU contribution € 0,00 Address Albinusdreef 2 Rc leiden See on map Links Website Opens in new window NATIONAL PUBLIC HEALTH INSTITUTE Finland EU contribution € 0,00 Address Mannerheimintie 166 Helsinki See on map Links Website Opens in new window ERNST-MORITZ-ARNDT-UNIVERSITY Germany EU contribution € 0,00 Address Klinikum/sauerbruchstrasse Greifswald See on map Links Website Opens in new window UPPSALA UNIVERSITY Sweden EU contribution € 0,00 Address Husargatan 3 Uppsala See on map Links Website Opens in new window CENTRE EUROPÉEN D'ÉTUDE DU DIABÈTE' France EU contribution € 0,00 Address Boulevard rené leriche Strasbourg See on map Links Website Opens in new window FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE Spain EU contribution € 0,00 Address Gran vía s/n km. 2,7 L´hospitalet de llobregat ( barcelona ) See on map Links Website Opens in new window INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALA France EU contribution € 0,00 Address 251, rue du faubourg saint martin Paris See on map Links Website Opens in new window UNIVERSITÀ DEGLI STUDI DI SIENA Italy EU contribution € 0,00 Address Banchi di sotto, 55 Siena See on map Links Website Opens in new window