European Vascular Genomics Network

Objective

Cardiovascular diseases (CVD) caused 51% of deaths in Europe in 2001.Coronary heart disease and stroke, which result from atherosclerosis, constitute 80% of CVD. Better prevention and treatments have halved age-specific incidence, but the ageing population and adverse trends in obesity and diabetes threaten these improvements. There is also an alarming increase in heart failure, the end stage of coronary heart disease. Future advances depend on developing entirely new strategies. Genomics and proteomics together complete human genome open up fresh horizons for molecular understanding of cardiovascular disease, for identifying new diagnostic measurements and developing new pharmacological, gene and cell-based therapies. The European Vascular Genomics Network (EVGN) assembles the necessary critical mass and promotes multidisciplinary interactions by uniting 25 world-leading basic and clinical institutions from 9 European countries. It focusses on the three areas with greatest therapeutic potential: 1) endothelial dysfunction, an early critical event in atherosclerosis and hence a target for prevention, 2) plaque instability, responsible for precipitating thrombosis and hence most life-threatening acute events, and 3) therapeutic angiogenesis either conventional or cell-based to recover ischaemic organ function and reduce heart failure. Our research armoury spans genomics, proteomics, molecular biology, cell biology, gene transfer and genetic modification in mice, and integrative pathophysiology in man. The EVGN will maximize the scientific and commercial potential of European vascular biology by electronic data-sharing and communication networks, shared research tools, and exchange and training programmes. The EVGN will train tomorrow's lead investigators through a European training programme for PhD students, which will also address adverse gender balance and encourage excellence in Eastern Europe, which suffers high prevalence of CVD.

Fields of science

• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• natural sciences › biological sciences › cell biology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › biological sciences › molecular biology
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy

Programme(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

• LIFESCIHEALTH-2.1.1 - Combating cardiovascular diseases, diabetes, and rare diseases

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

Address

101, Rue De Tolbiac
Paris
France

Participants (33)

THE UNIVERSITY OF BRISTOL

United Kingdom

Address

Senate House, Tyndalls Avenue
Bristol

CHANCELLORS MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

Address

The Old Schools, Trinity Lane
Cambridge

CARDIOVASCULAR RESEARCH INSTITUTE MAASTRICHT

Netherlands

Address

Universiteitssingel 50 (Um5 50/N)
Maastricht

KAROLINSKA INSTITUTET

Sweden

Address

Stockholm

FONDAZIONE IFOM ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

Italy

Address

Via Adamello, 16
Milan

UNIVERSITY OF ZURICH

Switzerland

Address

Raemistrasse 71
Zurich

MEDICAL UNIVERSITY VIENNA

Austria

Address

Spitalgasse 23
Vienna

VU MEDICAL CENTER

Netherlands

Address

De Boelelaan 1117
Amsterdam

ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM

Netherlands

Address

Meibergdreef 9, 1105 Az
Amsterdam

VITA-SALUTE SAN RAFFAELE UNIVERSITY

Italy

Address

Via Olgettina 58
Milan

UNIVERSITY OF KUOPIO

Finland

Address

Savilahdentie 9
1627 Kuopio

UNIVERSITY OF TORINO

Italy

Address

Via Verdi 8
Torino

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Italy

Address

Viale Delle Medaglie D'oro, 305'
Rome

ST. GEORGE'S HOSPITAL MEDICAL SCHOOL'

United Kingdom

Address

Cranmer Terrace Tooting
London

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

Address

The Authority For Research And Development, Edmond J. Safra Campus, Givat Ram
Jerusalem

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

Address

Edgbaston
Birmingham

UNIVERSITY COLLEGE LONDON

United Kingdom

Address

Gower Street
London

UNIVERSITY OF GENEVA

Switzerland

Address

Rue General Dufour 24
Geneva 4

ARK THERAPEUTICS GROUP LIMITED

United Kingdom

Address

1 Fitzroy Mews
London

TECHNOCLONE GMBH

Austria

Address

Brunner Strasse 59/5
Vienna

INSERM-TRANSFERT SA

France

Address

101 Rue De Tolbiac
Paris

JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE

Poland

Address

Sw Anny 12
Krakow

JAGIELLONIAN UNIVERSITY

Poland

Address

Golebia 24
Krakow

SILESIAN SCHOOL OF MEDECINE

Poland

Address

Warszaloska 14
Katowice

KING'S COLLEGE LONDON

United Kingdom

Address

Strand
London

CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET EN MÉDECINE (GIE)

France

Address

1 Rue Laurent Fries
Illkirch

FONDAZIONE ITALIANA PER LA RICERCA SUL CANCRO ONLUS

Italy

Address

Via Corridoni, 7
Milano

JOHANN WOLFGANG GOETHE-UNIVERSITÄT

Germany

Address

Senckenberganlage 31
Frankfurt Am Main

JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

Germany

Address

Saarstrasse 21
Mainz

MEDIZINISCHE UNIVERSITÄT INNSBRUCK

Austria

Address

Innrain 52
Innsbruck

RHEINISCHE-FREIDRICH-WILHEMS-UNIVERSITÄT MEDIZINISCHE FAKULTÄT BONN

Germany

Address

Medizinische Fakultät, Haus 13, Sigmund-freud-strasse 25
Bonn

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

Address

Martinistrasse 52
Hamburg

UNIVERSITÄT LEIDEN

Netherlands

Address

Einsteinweg 55
Leiden