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European Vascular Genomics Network

Objective

Cardiovascular diseases (CVD) caused 51% of deaths in Europe in 2001.Coronary heart disease and stroke, which result from atherosclerosis, constitute 80% of CVD. Better prevention and treatments have halved age-specific incidence, but the ageing population and adverse trends in obesity and diabetes threaten these improvements. There is also an alarming increase in heart failure, the end stage of coronary heart disease. Future advances depend on developing entirely new strategies. Genomics and proteomics together complete human genome open up fresh horizons for molecular understanding of cardiovascular disease, for identifying new diagnostic measurements and developing new pharmacological, gene and cell-based therapies. The European Vascular Genomics Network (EVGN) assembles the necessary critical mass and promotes multidisciplinary interactions by uniting 25 world-leading basic and clinical institutions from 9 European countries. It focusses on the three areas with greatest therapeutic potential: 1) endothelial dysfunction, an early critical event in atherosclerosis and hence a target for prevention, 2) plaque instability, responsible for precipitating thrombosis and hence most life-threatening acute events, and 3) therapeutic angiogenesis either conventional or cell-based to recover ischaemic organ function and reduce heart failure. Our research armoury spans genomics, proteomics, molecular biology, cell biology, gene transfer and genetic modification in mice, and integrative pathophysiology in man. The EVGN will maximize the scientific and commercial potential of European vascular biology by electronic data-sharing and communication networks, shared research tools, and exchange and training programmes. The EVGN will train tomorrow's lead investigators through a European training programme for PhD students, which will also address adverse gender balance and encourage excellence in Eastern Europe, which suffers high prevalence of CVD.

Field of science

  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
Address
101, Rue De Tolbiac
Paris
France

Participants (33)

THE UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndalls Avenue
Bristol
CHANCELLORS MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
CARDIOVASCULAR RESEARCH INSTITUTE MAASTRICHT
Netherlands
Address
Universiteitssingel 50 (Um5 50/N)
Maastricht
KAROLINSKA INSTITUTET
Sweden
Address

Stockholm
FONDAZIONE IFOM ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
Address
Via Adamello, 16
Milan
UNIVERSITY OF ZURICH
Switzerland
Address
Raemistrasse 71
Zurich
MEDICAL UNIVERSITY VIENNA
Austria
Address
Spitalgasse 23
Vienna
VU MEDICAL CENTER
Netherlands
Address
De Boelelaan 1117
Amsterdam
ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM
Netherlands
Address
Meibergdreef 9, 1105 Az
Amsterdam
VITA-SALUTE SAN RAFFAELE UNIVERSITY
Italy
Address
Via Olgettina 58
Milan
UNIVERSITY OF KUOPIO
Finland
Address
Savilahdentie 9
1627 Kuopio
UNIVERSITY OF TORINO
Italy
Address
Via Verdi 8
Torino
NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS
Italy
Address
Viale Delle Medaglie D'oro, 305'
Rome
ST. GEORGE'S HOSPITAL MEDICAL SCHOOL'
United Kingdom
Address
Cranmer Terrace Tooting
London
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmond J. Safra Campus, Givat Ram
Jerusalem
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
Birmingham
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
UNIVERSITY OF GENEVA
Switzerland
Address
Rue General Dufour 24
Geneva 4
ARK THERAPEUTICS GROUP LIMITED
United Kingdom
Address
1 Fitzroy Mews
London
TECHNOCLONE GMBH
Austria
Address
Brunner Strasse 59/5
Vienna
INSERM-TRANSFERT SA
France
Address
101 Rue De Tolbiac
Paris
JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE
Poland
Address
Sw Anny 12
Krakow
JAGIELLONIAN UNIVERSITY
Poland
Address
Golebia 24
Krakow
SILESIAN SCHOOL OF MEDECINE
Poland
Address
Warszaloska 14
Katowice
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET EN MÉDECINE (GIE)
France
Address
1 Rue Laurent Fries
Illkirch
FONDAZIONE ITALIANA PER LA RICERCA SUL CANCRO ONLUS
Italy
Address
Via Corridoni, 7
Milano
JOHANN WOLFGANG GOETHE-UNIVERSITÄT
Germany
Address
Senckenberganlage 31
Frankfurt Am Main
JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
Germany
Address
Saarstrasse 21
Mainz
MEDIZINISCHE UNIVERSITÄT INNSBRUCK
Austria
Address
Innrain 52
Innsbruck
RHEINISCHE-FREIDRICH-WILHEMS-UNIVERSITÄT MEDIZINISCHE FAKULTÄT BONN
Germany
Address
Medizinische Fakultät, Haus 13, Sigmund-freud-strasse 25
Bonn
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Address
Martinistrasse 52
Hamburg
UNIVERSITÄT LEIDEN
Netherlands
Address
Einsteinweg 55
Leiden