Objective
Validated alternative test methods are urgently required for safety toxicology of drugs, chemicals and cosmetics. While some animal tests for topical toxicity have been successfully replaced one by one by alternative methods, systemic toxicities require new test strategies in order to achieve an adequate safety level of the consumer. In the project, ECVAM takes the lead to manage the development of a conceptual framework in the area of reproductive toxicity. The involvement of all stakeholders in the Project Board including the European Consensus Platform on Alternatives (ECOPA), European regulators, OECD, and Industry guarantees an efficient problem solving approach. Reproductive toxicity offers the opportunities that: i) a substantial number of animals are currently required in in-vivo assays; ii) the reproductive system can be broken down into well-defined sub-elements covering the reproductive cycle; iii) a number of pioneering alternatives have already been developed; and iv) the same animal experiments are carried out for drugs, chemicals and cosmetics.
The project is composed of four elements, i.e.
a) technological development of in vitro and
b) sensor technologies
c) the strategical development of a conceptual framework
d) the dissemination and implementation activities.
The project will develop the concepts required to compose testing strategies via the continuous implementation of novel in vitro and in silico alternatives. Problems to be solved include the development of substantial numbers of alternative test methods making use of advanced technologies. This approach requires the dimensions of a transnational Integrated Project, involving some of the most prominent reproductive toxicity research groups in the EU, close monitoring by and input from the regulatory community and professional managerial steering. In return, it offers the realistic opportunity to achieve a substantial reduction of animal experiment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences basic medicine toxicology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TUEBINGEN
Germany
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Participants (32)
2040 ROTTERDAM
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AMSTERDAM
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BILTHOVEN
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BRUSSELS
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BEERSE
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LA SERRA DI SAN MINIATO (PI)
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ROME
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LONDON
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BP 159 AMBOISE
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330013 BERLIN
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BERLIN
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100554 MAINZ
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HANNOVER
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M655 KONSTANZ
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256 UPPSALA
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BOURGAS
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VIENNA
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MILANO
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271 LIVERPOOL
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ZELLIK (BRUSSELS)
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6060 DELFT
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ROMA
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MOL
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2177 COPENHAGEN
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580 ISPRA
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TRES CANTOS (MADRID)
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KONSTANZ
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MILAN
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79095 FREIBURG
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1627 KUOPIO
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SIENA
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CREMONA
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