Objective
The Eicosanoids and nitric oxide (NO) are important signalling molecules in many physiological and pathological pro-cesses, including cardiovascular, cerebral and neoplastic disorders. Together, these diseases account for the vast maj-ority of deaths in Europe and represent an enormous health problem with a major socio-economic impact. We have assembled a large and highly competitive Consortium, positioned at the forefront of eicosanoid and NO research. The partners will jointly carry out an ambitious project, aiming to increase the knowledge of these autacoids, with the goal to develop novel therapeutic strategies and medical treatments.
We will carry out molecular studies on key enzymes and receptors to elucidate biochemical properties, catalytic mechan-isms and structure-function relationships. We will address the functional genomics of the Eicosanoid and NO cascades to characterize gene expression profiles and regulation under normal and disease states, and identify novel potential drug targets. New genes will be characterized using proteomics, structural genomics and model organisms. In parallel, the partners will conduct cell biological work on gene regulation, gene silencing, signalling systems and cross-talk between pathways. This information will be used in studies of disease mechanisms such as inflammation, immune responses and angiogenesis. In turn, these insights in pathology will be translated into investigations of diseases using animal models and clinical applications.
The basic research together with applied and clinical studies will act in synergy to identify novel targets for pharmacolo-gical intervention and drug design for the treatment of patients suffering from cardiovascular, cerebral and neoplastic disorders. Moreover, our Consortium will work in alliance with industry and is expected to generate an integrated infra-structure for R&D, training and mobility of researchers, exploitation and dissemination.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine immunology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.