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European integrated project on spinocerebellar ataxias (EUROSCA): Pathogenesis, genetics, animal models and therapy

Objective

Twenty two European groups from 9 countries with an excellent reputation of clinical, clinical-genetic and basic research on spinocerebellar ataxias (SCA) will jointly form an Integrated project to develop a treatment for patients suffering from this rare, late manifesting, and autosomal dominant inherited group of neurodegenerative diseases. To reach this goal, an international standard on the clinical evaluation in form of a Core Assessment Program for Interventional Therapies of SCA (CAPIT-SCA) will be developed based on clinical rating scales, structural imaging, and electrophysiology. The generation of the world largest collection of information on SCA, the European SCA Registry (EUROSCA-R), will ensure standardized data acquisition.

This powerful tool will facilitate continuous recruitment of SCA patients throughout Europe for linkage analysis, identification of novel ataxia genes and natural history studies. The potential to include all larger European SCA families into linkage analysis will lead to the identification of new SCA loci and to the cloning of novel ataxia genes, respectively. Genotype-phenotype correlations will follow. Subsequently, for the first time such a combined effort will offer a systematic large-scale search for genetic modifier factors in SCA allowing a better comprehension of factors accounting for wide clinical variability with application for prognosis and to identify new potential targets (modifier genes). EUROSCA will also implement strong research projects to generate and characterize cellular and transgenic models, which will allow a more defined study of the pathogenesis and will serve as a tool for first therapeutic studies. 9 European research groups will be supported by five core facilities such as transgenic Drosophila work, Expression-Chip-Technology, Proteomics, yeast two hybrid technology, and monoclonal antibodies. Training programs will complement research efforts and clinical work.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Funding Scheme

IP - Integrated Project

Coordinator

EBERHARD-KARLS-UNIVERSITÄT TÜBINGEN
Address
Wilhelmstr. 5
Tübingen
Germany

Participants (20)

UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
UNIVERSITY CLINIC BONN
Germany
Address
Sigmund-freud-str.25
Bonn
ISTITUTO NAZIONALE NEUROLOGICO CARLO BESTA
Italy
Address
Via Celoria 11
Milan
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
STICHTING KATHOLIEKE UNIVERSITEIT, UNIVERSITY MEDICAL CENTER NIJMEGEN
Netherlands
Address
Geert Grooteplein 10
Nijmegen
INSTITUTE OF PSYCHIATRY AND NEUROLOGY WARSAW
Poland
Address
Sobieskiego 9
Warsaw
RUHR-UNIVERSITY BOCHUM
Germany
Address
Universitätsstr. 150
Bochum
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3, Rue Michel-ange
Paris
CENTRE EUROPEAN FOR RESEARCH IN BIOLOGY AND MEDICINE
France
Address
1, Rue Laurent Fries
Iiikirch
BIRKBECK COLLEGE, UNIVERSITY OF LONDON
United Kingdom
Address
Malet Street
London
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
Address
Carretera De Canyet S/n
Badalona
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101, Rue De Tolbiac
Paris
KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITÄT
Germany
Address
Theodor Stern Kai 7
Frankfurt/main
MAX DELBRÜCK CENTRUM FOR MOLECULAR MEDICINE
Germany
Address
Robert-rössle-str. 10
Berlin
SERVCIO CÁNTABRO DE SALUD
Spain
Address
Avda. Valdecilla S/n
Santander
UNIVERSITY OF PÉCS
Hungary
Address
Szigeti 12.
Pécs
UNIVERSITÄTSKLINIKUM LÜBECK
Germany
Address
Ratzeburger Allée, 160
Luebeck
UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS
Germany
Address
Robert-koch-str. 40
Goettingen
UNIVERSITÉ LIBRE DE BRUXELLES
Belgium
Address
Avenue Fd Roosevelt 50
Brussels