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The Development of Immunotherapeutic Strategies to Treat Haematological and Neoplastic diseases on the Basis of Optimised Allogeneic Stem Cell Transplantation

Objective

Haematological disease, either malignant or otherwise, carries a significant burden of morbidity and mortality. Recent advances in mapping and sequencing of the human genome make possible an approach to the treatment of these diseases which exploits the genetic differences between individuals to produce targets through which the immune system can eliminate the diseased cells. In practice this process of immunotherapy involves an allogeneic haematopoietic stem cell transplant, with subsequent delivery of specific immune effector cells expanded from the donor. The AlloStem project brings together clinical and research groups from across the EU who individually is amongst the world leaders in the field of immunotherapy to coordinate and complement their efforts into a unified and directed program. We will develop new protocols for the treatment of patients with haematological disease and for the effective delivery of immunogenomics-based therapies. The end results of the project will be both an improvement in the health care for EU citizens and the development of new genome-based pharmaceuticals that can be exploited worldwide.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Coordinator

THE ANTHONY NOLAN TRUST
Address
The Royal Free Hospital, Pond Street, Hampstead
London
United Kingdom

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Participants (28)

ALLOSTEM
United Kingdom
Address
The Royal Free Hospital, Pond Street, Hampstead
London

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BAYERISCHE JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG
Germany
Address
Sanderring 2
Wuerzburg

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-DELEGATION PROVENCE
France
Address
31, Chemin Joseph Aiguier
Marseille

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CHARLES UNIVERSITY PRAGUE, 2ND MEDICAL SCHOOL, INSTITUTE OF IMMUNOLOGY
Czechia
Address
V Úvalu 84
Prague 5

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DYNAL BIOTECH ASA
Norway
Address
Ullernchausseen 52
Oslo

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DYNAL BIOTECH LTD
United Kingdom
Address
11 Bassendale Rd, Croft Business Park
Bromborough, Wirral

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EBERHARD KARLS UNIVERSITÄT TÜBINGEN
Germany
Address
Wilhefmstr.7
Tübingen

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HELMHOLTZ ZENTRUM MUENCHEN- DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Address
Ingolstädter Landstr.1
Neuherberg

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HLA ET MEDECINE
France
Address
Ecole De Medecine 15
Paris

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Links
HOSPITAL DE CLINICAS, UNIVERSIDADE FEDERAL DO PARANA
Brazil
Address
Rua General Carneiro 181 15°andar
Curitiba

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INNATE PHARMA SAS
France
Address
121 Ancien Chemin De Cassis
Marseille

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INSITUT GUSTAVE ROUSSY
France
Address
39 Rue Camille Desmoulins
Villejuif

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IRCCS POLICLINICO SAN MATTEO
Italy
Address
Viale Golgi 19
Pavia

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ISTITUTO GIANNINA GASLINI
Italy
Address
Largo Gerolamo Gaslini 5
Genova

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ITMO-FUNDACIÓN MAINETTI - INSTITUTO DE TRASPLANTE DE MÉDULA OSEA
Argentina
Address
Calle 508 Entre 16 Y 18
Gonnet

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Links
KAROLINSKA INSTITUTET
Sweden
Address

Stockholm

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L: HIRSZFELD INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY, POLISH ACADEMY OF SCIENCES
Poland
Address
Rudolf Weigl 12
Wroclaw

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LEIDEN UNIVERSITY MEDICAL CENTER
Netherlands
Address
Albinusdreef 2
Leiden

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MILTENYI BIOTEC GMBH
Germany
Address
Friedrich-ebert Str.68
Bergish-gladbach

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PROIMMUNE LIMITED
United Kingdom
Address
Oxford Biobusiness Centre, Littlemore Park
Oxford

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SERVEIS DE REFERENCIA DE CATALUNYA - CENTRE DE TRANSFUSIO I BANC DE TEIXITS
Spain
Address
Pg. Vall D'heron 119-129'
Barcelona

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STATE RESEARCH CENTER, INSTITUTE OF IMMUNOLOGY
Russia
Address
Kashirskoye Shosse 24 B 2
Moscow

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THE NOTTINGHAM TRENT UNIVERSITY
United Kingdom
Address
Burton Street
Nottingham

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THE UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh

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UNIVERSIDAD AUTONOMA DE MADRID
Spain
Address
Carretera De Colmenar,km. 15
Madrid

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UNIVERSITY OF GENOVA-DIPARTIMENTO DI MEDICINA SPERIMENTALE
Italy
Address
Via Balbi 5
Genova

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UNIVERSITY OF PERUGIA
Italy
Address
Piazza Dell'università 1'
Perugia

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WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Rehovot
Rehovot

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