Objective
BACKGROUND: Proteinuria is a sign of kidney involvement in association with common infectious, inflammatory, immunological or metabolic (diabetes) diseases. When persisting, proteinuria leads to scarring and end-stage kidney disease requiring dialysis or renal transplantation. Both treatments are chronically debilitating, increase risk for severe secondary complications and are extremely expensive. Altogether, kidney complicationsconstitute more than 15% of total health-care costs in most Western countries, mainly due to increasing prevalence of diabetes-associated kidney disease.
PROBLEM: Earlier diagnostics is urgently needed to target intensive treatment efforts and to avoid the projectedexplosive increase in the number of kidney patients in near future. Due to the demographic trends, kidney diseases are a particular problem for Europe. At present, the diagnostics include serum markers (mostly non- sensitive, non-specific) and urine analysis (too late markers) but relies mainly on patient kidney biopsy samples. Although accurate, this procedure is severely inconvenient, invasive and carries a notable risk for complications.
SOLUTION: We propose to use the latest molecular information of verified pathogenetic routes, proprietary bio informatics platforms, well established in vivo models as well as extensive human sample repositories together with the SME activities to establish and validate new diagnostics. This includes the identification of an expanding set of key molecular markers directly from patient urine to yield novel measurable for early and accurate non-invasive diagnostics. With the set of markers accurately reflecting pathophysiologic changes we expect to replace the traditional kidney biopsies with more patient-friendly, accurate and economical diagnostics directly from urine, easily accessible source. Development will also allow construction of distant monitoring diaqnostic platforms to prevent permanent kidney.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine nephrology kidney diseases
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HELSINKI
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.