Epigenetic plasticity of the Genome

Objective

In this 'post-genomic' era, advances in epigenetic research represent a new frontier that is predicted to yield novel insights for gene regulation, cell differentiation, stem cell plasticity, organismal development, human diseases, cancer, infertility and aging. A central emerging concept proposes that there is an 'epigenetic code', which considerably extends the information potential of the genetic code. Thus, one genome can generate many 'epigenomes' as the fertilised egg progresses through development and translates its information into a multitude of cell fates. Research into epigenetics touches on many topics of key interest to the general public, including embryonic and adult stem cells, and is anticipated to have far-reaching implications for medicine and the understanding of the basic processes of cell fate determination. The resulting developments will undoubtedly impact academic and industrial research communities and will form an important knowledge base for policy makers and public bodies that contribute to the socio-economic future of our 'post-genomic' society. Europe has many world leading laboratories in epigenetic research. This network of excellence proposes to follow a progressively expanding strategy. For its initial establishment, 24 teams with a proven record as leaders in their field, will constitute a 'virtual core centre' to combine their expertise and resources. An immediate structuring role is provided by the concentration of these 24 teams around 8 established centres of epigenetic research. In defining a coordinated joint programme of activities, this NoE will assimilate existing synergies for building a structure that can feed three important needs: to advance scientific discoveries, integrate European research and establish an open dialogue. To achieve these three goals, the core NoE will make £ 50% of the grant available for network development and the durable shaping of a coherent European Research #'

Programme(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

• LSH-2002-1.1.5-5 - Epigenetics: chromatin dynamics, non-coding RNA, imprinting and silencing

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

FORSCHUNGSINSTITUT FÜR MOLEKULARE PATHOLOGIE GES.M.B.H.

Address

Dr. Bohr-gasse 7
Vienna
Austria

Participants (29)

RUPRECHT-KARLS-UNIVERSITY HEIDELBERG

Germany

Address

Seminarstrasse 2
Heidelberg

DEUTSCHES KREBSFORSCHUNGSZENTRUM

Germany

Address

Im Neuenheimer Feld 280
Heidelberg

SAARLAND UNIVERSITY

Germany

Address

Saarbrücken

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

Address

Geschwister-scholl-platz 1
Muenchen

ERASMUS MEDICAL CENTER ROTTERDAM

Netherlands

Address

Dr Molewaterplein 50
Rotterdam

THE UNIVERSITY OF EDINBURGH

United Kingdom

Address

Old College, South Bridge
Edinburgh

MEDICAL RESEARCH COUNCIL

United Kingdom

Address

20 Park Crescent
London

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

Address

Edgbaston
Birmingham

THE CHANCELLOR, MASTERS & SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

Address

The Old Schools, Trinity Lane
Cambridge

UNIVERSITY OF LEEDS

United Kingdom

Address

Woodhouse Lane
Leeds

INSTITUT CURIE AND CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Rue D'ulm, 26
Paris

INSTITUT PASTEUR

France

Address

25 Rue Du Docteur Roux
Paris

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

Address

Meyerhofstrasse 1
Heidelberg

KAROLINSKA INSTITUTET

Sweden

Address

Stockholm

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Address

147 Rue De L'université
Paris

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Route De Mende N°1919
Montpellier

NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

Address

Plesmanlaan 121
Amsterdam

FONDAZIONE TELETHON

Italy

Address

Via G. Saliceto, 5
Rome

NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

Switzerland

Address

Maulbeerstrasse 66
Basel

INSTITUTE OF MOLECULAR BIOTECHNOLOGY GMBH

Austria

Address

Dr.-bohr-gasse 3
Vienna

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

Address

Hofgartenstrasse 8
Muenchen

CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GES.M.B.H.

Austria

Address

Schopenhauerstrasse 40/3/18
Vienna

EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH

Switzerland

Address

Raemistrasse 101
Zurich

FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III

Spain

Address

C/ Melchor Fernández Almagro, 3
Madrid

GMI - GREGOR MENDEL INSTITUT FÜR MOLEKULARE PFLANZENBIOLOGIE GMBH

Austria

Address

Dr. Bohr-gasse 3
Vienna

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

Address

251 Rue Du Faubourg Saint Martin
Paris

MARTIN-LUTHER-UNIVERSITÄT HALLE-WITTENBERG

Germany

Address

Halle (Saale)

UNIVERSITY OF ZÜRICH

Switzerland

Address

Rämistrasse 71
Zürich

UNIVERSITÉ DE GENÈVE

Switzerland

Address

24, Rue Du General-dufour
Geneva