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Epigenetic plasticity of the Genome

Objective

In this 'post-genomic' era, advances in epigenetic research represent a new frontier that is predicted to yield novel insights for gene regulation, cell differentiation, stem cell plasticity, organismal development, human diseases, cancer, infertility and aging. A central emerging concept proposes that there is an 'epigenetic code', which considerably extends the information potential of the genetic code. Thus, one genome can generate many 'epigenomes' as the fertilised egg progresses through development and translates its information into a multitude of cell fates. Research into epigenetics touches on many topics of key interest to the general public, including embryonic and adult stem cells, and is anticipated to have far-reaching implications for medicine and the understanding of the basic processes of cell fate determination. The resulting developments will undoubtedly impact academic and industrial research communities and will form an important knowledge base for policy makers and public bodies that contribute to the socio-economic future of our 'post-genomic' society. Europe has many world leading laboratories in epigenetic research. This network of excellence proposes to follow a progressively expanding strategy. For its initial establishment, 24 teams with a proven record as leaders in their field, will constitute a 'virtual core centre' to combine their expertise and resources. An immediate structuring role is provided by the concentration of these 24 teams around 8 established centres of epigenetic research. In defining a coordinated joint programme of activities, this NoE will assimilate existing synergies for building a structure that can feed three important needs: to advance scientific discoveries, integrate European research and establish an open dialogue. To achieve these three goals, the core NoE will make £ 50% of the grant available for network development and the durable shaping of a coherent European Research #'

Call for proposal

FP6-2002-LIFESCIHEALTH
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Coordinator

FORSCHUNGSINSTITUT FÜR MOLEKULARE PATHOLOGIE GES.M.B.H.
Address
Dr. Bohr-gasse 7
Vienna
Austria

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Participants (29)

RUPRECHT-KARLS-UNIVERSITY HEIDELBERG
Germany
Address
Seminarstrasse 2
Heidelberg

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DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
Heidelberg

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SAARLAND UNIVERSITY
Germany
Address

Saarbrücken

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LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Muenchen

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ERASMUS MEDICAL CENTER ROTTERDAM
Netherlands
Address
Dr Molewaterplein 50
Rotterdam

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THE UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh

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MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London

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THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
Birmingham

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THE CHANCELLOR, MASTERS & SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge

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UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds

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INSTITUT CURIE AND CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue D'ulm, 26
Paris

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INSTITUT PASTEUR
France
Address
25 Rue Du Docteur Roux
Paris

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EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg

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KAROLINSKA INSTITUTET
Sweden
Address

Stockholm

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INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
147 Rue De L'université
Paris

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Route De Mende N°1919
Montpellier

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NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
Address
Plesmanlaan 121
Amsterdam

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FONDAZIONE TELETHON
Italy
Address
Via G. Saliceto, 5
Rome

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NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Switzerland
Address
Maulbeerstrasse 66
Basel

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INSTITUTE OF MOLECULAR BIOTECHNOLOGY GMBH
Austria
Address
Dr.-bohr-gasse 3
Vienna

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MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
Muenchen

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CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GES.M.B.H.
Austria
Address
Schopenhauerstrasse 40/3/18
Vienna

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EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH
Switzerland
Address
Raemistrasse 101
Zurich

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FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III
Spain
Address
C/ Melchor Fernández Almagro, 3
Madrid

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GMI - GREGOR MENDEL INSTITUT FÜR MOLEKULARE PFLANZENBIOLOGIE GMBH
Austria
Address
Dr. Bohr-gasse 3
Vienna

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INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
251 Rue Du Faubourg Saint Martin
Paris

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MARTIN-LUTHER-UNIVERSITÄT HALLE-WITTENBERG
Germany
Address

Halle (Saale)

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UNIVERSITY OF ZÜRICH
Switzerland
Address
Rämistrasse 71
Zürich

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UNIVERSITÉ DE GENÈVE
Switzerland
Address
24, Rue Du General-dufour
Geneva

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