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Translational and Functional Onco-Genomics: from cancer-oriented genomic screenings to new diagnostic tools and improved cancer treatment.

Objective

The TRANSFOG project aims at the systematic identification and functional characterization of novel cancer genes with high potential diagnostic and therapeutic value. The TRANSFOG Partners will bring together world recognised competences and resources to reach the following, integrated research objectives: 1) identification of novel candidate cancer genes through cancer-oriented genomic screenings, using tumour tissues as well as cellular and animal models, to generate a prioritized panel of genes involved in breast, colon and lung cancer progression and metastasis; 2) Full-length cDNA collection of the identified candidates, and setup of systems for high-throughput in vitro and in vivo gene delivery; 3) Collection of retroviral expression plasmids encoding small interfering RNAs, for systematic downregulation of candidate genes; 4) identification of new molecular targets for cancer therapy, which will involve adaptation of existing cell-based and model organisms assays to a high throughput configuration, for systematic analysis of gene gain- and loss-of function of the identified candidate genes, using vectors developed under Activities 2 and 3, and selection of genes for preclinical, proof-of concept validation of novel therapeutic targets; 5) Proteomic analysis of signal transduction and protein-protein interaction; focussed on the candidate cancer genes; this will allow better dissection of aberrant cancer signalling pathways. 6)Validation of the diagnostic potential of the identified cancer genes, towards the clinical use of diagnostic molecular signatures; 7) Generation of a shared informatic platform for data handling and gene functional annotation. This will greatly increase Europe competitiveness, provide a huge structuring effect on the ERA in the field of functional oncogenomics, and depict several new molecular targets for anticancer drugdiscovery and for advanced cancer diagnosis.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Coordinator

GROUPEMENT EUROPEEN D'INTÉRÊT ECONOMIQUE - LIAISON NETWORK FOR CANCER
Address
Rue D'agmont 11
Brussels
Belgium

Participants (21)

AGENDIA BV
Netherlands
Address
Slotervaart Medical Center 9D, Louwesweg 6
Amsterdam
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRL-ALTA SRL
Italy
Address
Via Fiorentina 1
Siena
BIOMEDICAL SCIENCES RESEARCH CENTRE " ALEXANDER FLEMING"
Greece
Address
34 Fleming Street
Vari
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS
Spain
Address
Sinesio Delgado, 6
Madrid
CONSORZIO INTERUNIVERSITARIO BIOTECNOLOGIE
Italy
Address
Area Science Park, Padriciano 99
Trieste
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
Heidelberg
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg
FONDAZIONE PIEMONTESE PER LA RICERCA SUL CANCRO- ONLUS
Italy
Address
Strada Provinciale 142, Km 3.95
Candiolo (To)
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
Address
Via Adamello, 16
Milan
KAROLINSKA INSTITUTET
Sweden
Address
Solnavaegen 1
Stockholm
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
LUDWIG INSTITUT FUER KREBSFORSCHUNG
Switzerland
Address
Stadelhoferstrasse 222
Zurich
LUDWIG INSTITUT FÜR KREBSFORSCHUNG
Switzerland
Address
Stadelhoferstrasse 222
Zurich
LUDWIG INSTITUT FÜR KREBSFORSCHUNG
Sweden
Address
Stadelhoferstrasse 222
Zurich
LUDWIG INSTITUT FÜR KREBSFORSCHUNG
Sweden
Address
Stadelhoferstrasse 222
Zurich
MAX-DELBRUECK-CENTER FOR MOLECULAR MEDICINE BERLIN
Germany
Address
Robert-roessle-strasse 10
Berlin
MEDIZIN UNIVERSITÄT INNSBRUCK
Austria
Address
Innrain 52
Innsbruck
NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Switzerland
Address
Maulbeerstrasse 66 (Ch-4058)
Basel
THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
Plesmanlaan 121
Amsterdam
UNIVERSITY MEDICAL CENTER UTRECHT
Netherlands
Address
Universiteitsweg 100
Utrecht
WEIZMANN INSTITUTE OF SCIENCE
Israel