Objective Nearly all aspects of cell life (and death) are controlled by protein phosphorylation catalysed by protein kinases (PKs). PKs belong to the largest single family of enzymes, numbering over 500 and accouting for almost 2% of the proteins encoded by the human genome. Recent success in drug discovery (e.g. Imatinib, GlivecR) demonstrate that PKs are excellent drug targets. The Pro-KinaseResearch consortium will combine European expertise on basic research on PKs and that on rational drug discovery, in order to develop new drug candidates and treatment strategies for major diseases like cancer, autoimmune disorders, vascular diseases and degenerative brain diseases. Thus, the aim of this IP is to study PKs as drug targets for more effective and better tolerated drug therapies meeting the needs of ageing population.The joint effort will focus on the biochemical properties and structure function relationships of a wide variety of PKs having the potential as pharmacological targets. We will evaluate the regulatory domains, catalytic domains and also anchoring proteins of various PKs, as drug targets. Natural compounds from European biosphere, e.g. Cyanobacteria, and compounds from combinatorial chemistry, chemical libraries, affecting activity of PKs will be analysed to gain knowledge of their structure/activity relationship. These compounds will be used as model drugs or templates for a rational drug design where new compounds will be modelled and synthesised. This consortium has a broad range of bioactivity assays to study the efficacy and toxicity of the new compounds. The consortium includes academic groups with unique expertise in biochemistry, structural crystallography, synthetic organic chemistry, lead structure optimisation and other fields of rational drug discovery; clinically oriented groups with proven experience in animal models and phase I-II clinical studies under GCP guidelines; and SME partners to assure a quick transfer of knowledge. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesbasic medicinemedicinal chemistrymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Keywords Protein kinase inhibitors drug discovery molecular modelling Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-1.2.1-1 - Screening for drug candidates targeting aberrant molecular signalling in protein phosphorylation pathways Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme IP - Integrated Project Coordinator UNIVERSITY OF HELSINKI Address Yliopistonkatu 4 University of helsinki Finland See on map Links Website Opens in new window EU contribution € 0,00 Participants (27) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE LAUSANNE Switzerland EU contribution € 0,00 Address Bep Lausanne See on map Links Website Opens in new window UNIVERSITY OF DUNDEE United Kingdom EU contribution € 0,00 Address Nethergate Dundee See on map Links Website Opens in new window UNIVERSITY OF DEBRECEN Hungary EU contribution € 0,00 Address Egyetem ter 1. Debrecen See on map Links Website Opens in new window UNIVERSITAT INNSBRUCK Austria EU contribution € 0,00 Address Innrain 52 Innsbruck See on map Links Website Opens in new window SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH Switzerland EU contribution € 0,00 Address Ramistrasse 101 Zurich See on map Links Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 0,00 Address University offices, wellington square Oxford See on map Links Website Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address 3,rue michel-ange Paris See on map Links Website Opens in new window ISTITUTO VENETO DI MEDICINA MOLECOLARE-CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS Italy EU contribution € 0,00 Address Via orus, 2 Padova See on map Links Website Opens in new window CANCER RESEARCH UK United Kingdom EU contribution € 0,00 Address 61 lincoln's inn fields' London See on map Links Website Opens in new window THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 0,00 Address The authority for research & development, edmond j. safra campus, givat ram Jerusalem See on map Links Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCSE MEDICALE (INSERM) France EU contribution € 0,00 Address 101, rue de tolbiac Paris See on map Links Website Opens in new window LUDWIG-MAXIMILLIANS-UNIVERSITAT MUNCHEN Germany EU contribution € 0,00 Address Geschwister-scholl-platz 1 Munich See on map Links Website Opens in new window UNIVERSITETET I BERGEN Norway EU contribution € 0,00 Address Prof. keysersgt. 8 Bergen See on map Links Website Opens in new window THE UNIVERSITY OF BIRMINGHAM United Kingdom EU contribution € 0,00 Address Edgbaston Birmingham See on map Links Website Opens in new window KTB TUMORFORSCHUNGS GMBH Germany EU contribution € 0,00 Address Breisacher strasse 117 Freiburg See on map Links Website Opens in new window C3 BIO GMBH Germany EU contribution € 0,00 Address Ottobrunner str 37 Unterhaching See on map NEUROKIN S.AR.L. France EU contribution € 0,00 Address Inmed, parc scientifique de luminy Marseilles See on map INTE:LIGAND SOFTWARE-ENTWICKLUNGS-UND CONSULTING GMBH Austria EU contribution € 0,00 Address Clemens maria hofbauer-g. 6 Maria enzersdorf See on map Links Website Opens in new window PEPSCAN SYSTEMS B.V. Netherlands EU contribution € 0,00 Address Zuidersluisweg 2 2098 Lelystad See on map Links Website Opens in new window TECHNICHE UNIVERSITAT CAROLO WILHELMINA ZU BRAUNSCHWEIG Germany EU contribution € 0,00 Address Pockelsstrasse 14 Braunschweig See on map Links Website Opens in new window MEDICAL UNIVERSITY OF INNSBRUCK Austria EU contribution € 0,00 Address Innrain 52 Innsbruck See on map Links Website Opens in new window PEPSCAN PRESTO B.V. Netherlands EU contribution € 0,00 Address Zuidersluisweg 2 2098 Lelystad See on map Links Website Opens in new window UNIVERSITE DE GENEVE Switzerland EU contribution € 0,00 Address 24, rue general-dufour Geneve 4 See on map Links Website Opens in new window UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA Italy EU contribution € 0,00 Address Piazza dell'ateneo nuovo 1 Milano See on map Links Website Opens in new window UNIVERSITY OF VIENNA Austria EU contribution € 0,00 Address Dr.-karl lueger-ring 1 Vienna See on map Links Website Opens in new window GAUSE INSTITUTE OF NEW ANTIBIOTICS Russia EU contribution € 0,00 Address 11 b.pirogovskaya street Moscow See on map AUTONOMOUS NON-COMMERCIAL RESEARCH CENTER OF BIOTECHNOLOGY OF ANTIBIOTICS Russia EU contribution € 0,00 Address 27 b.kommunisticheskaya street Moscow See on map