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Protein kinases - Novel Drug Targets of Post Genomic Era

Objective

Nearly all aspects of cell life (and death) are controlled by protein phosphorylation catalysed by protein kinases (PKs). PKs belong to the largest single family of enzymes, numbering over 500 and accouting for almost 2% of the proteins encoded by the human genome. Recent success in drug discovery (e.g. Imatinib, GlivecR) demonstrate that PKs are excellent drug targets. The Pro-KinaseResearch consortium will combine European expertise on basic research on PKs and that on rational drug discovery, in order to develop new drug candidates and treatment strategies for major diseases like cancer, autoimmune disorders, vascular diseases and degenerative brain diseases. Thus, the aim of this IP is to study PKs as drug targets for more effective and better tolerated drug therapies meeting the needs of ageing population.

The joint effort will focus on the biochemical properties and structure function relationships of a wide variety of PKs having the potential as pharmacological targets. We will evaluate the regulatory domains, catalytic domains and also anchoring proteins of various PKs, as drug targets. Natural compounds from European biosphere, e.g. Cyanobacteria, and compounds from combinatorial chemistry, chemical libraries, affecting activity of PKs will be analysed to gain knowledge of their structure/activity relationship. These compounds will be used as model drugs or templates for a rational drug design where new compounds will be modelled and synthesised. This consortium has a broad range of bioactivity assays to study the efficacy and toxicity of the new compounds. The consortium includes academic groups with unique expertise in biochemistry, structural crystallography, synthetic organic chemistry, lead structure optimisation and other fields of rational drug discovery; clinically oriented groups with proven experience in animal models and phase I-II clinical studies under GCP guidelines; and SME partners to assure a quick transfer of knowledge.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Coordinator

UNIVERSITY OF HELSINKI
Address
Yliopistonkatu 4
University Of Helsinki
Finland

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Participants (27)

UNIVERSITE DE LAUSANNE
Switzerland
Address
Bep
Lausanne

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UNIVERSITY OF DUNDEE
United Kingdom
Address
Nethergate
Dundee

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UNIVERSITY OF DEBRECEN
Hungary
Address
Egyetem Ter 1.
Debrecen

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UNIVERSITAT INNSBRUCK
Austria
Address
Innrain 52
Innsbruck

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SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH
Switzerland
Address
Ramistrasse 101
Zurich

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3,Rue Michel-ange
Paris

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ISTITUTO VENETO DI MEDICINA MOLECOLARE-CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS
Italy
Address
Via Orus, 2
Padova

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CANCER RESEARCH UK
United Kingdom
Address
61 Lincoln's Inn Fields'
London

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THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research & Development, Edmond J. Safra Campus, Givat Ram
Jerusalem

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCSE MEDICALE (INSERM)
France
Address
101, Rue De Tolbiac
Paris

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LUDWIG-MAXIMILLIANS-UNIVERSITAT MUNCHEN
Germany
Address
Geschwister-scholl-platz 1
Munich

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UNIVERSITETET I BERGEN
Norway
Address
Prof. Keysersgt. 8
Bergen

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THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
Birmingham

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KTB TUMORFORSCHUNGS GMBH
Germany
Address
Breisacher Strasse 117
Freiburg

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C3 BIO GMBH
Germany
Address
Ottobrunner Str 37
Unterhaching

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Links
NEUROKIN S.AR.L.
France
Address
Inmed, Parc Scientifique De Luminy
Marseilles

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INTE:LIGAND SOFTWARE-ENTWICKLUNGS-UND CONSULTING GMBH
Austria
Address
Clemens Maria Hofbauer-g. 6
Maria Enzersdorf

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PEPSCAN SYSTEMS B.V.
Netherlands
Address
Zuidersluisweg 2
2098 Lelystad

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TECHNICHE UNIVERSITAT CAROLO WILHELMINA ZU BRAUNSCHWEIG
Germany
Address
Pockelsstrasse 14
Braunschweig

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MEDICAL UNIVERSITY OF INNSBRUCK
Austria
Address
Innrain 52
Innsbruck

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PEPSCAN PRESTO B.V.
Netherlands
Address
Zuidersluisweg 2
2098 Lelystad

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UNIVERSITE DE GENEVE
Switzerland
Address
24, Rue General-dufour
Geneve 4

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UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
Italy
Address
Piazza Dell'ateneo Nuovo 1
Milano

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UNIVERSITY OF VIENNA
Austria
Address
Dr.-karl Lueger-ring 1
Vienna

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GAUSE INSTITUTE OF NEW ANTIBIOTICS
Russia
Address
11 B.pirogovskaya Street
Moscow

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AUTONOMOUS NON-COMMERCIAL RESEARCH CENTER OF BIOTECHNOLOGY OF ANTIBIOTICS
Russia
Address
27 B.kommunisticheskaya Street
Moscow

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