Objective
While bacteria remain one of the main threats to human health and well-being, particularly in the light of increasing resistance to antimicrobials, they also have the capacity to provide products (e.g. antibiotics, vaccines and biotherapeutics) that have a positive influence on human health. Thus, bacteria are both targets for, and producers of, biopharmaceuticals. BACELL HEALTH is a research and technological development project that aims to address both the negative and positive characteristics of bacterial behaviour by undertaking an integrated and in-depth study of the response of Gram-positive bacteria to stresses encountered by pathogens during infection and by industrial strains during bioprocesses. The ability of bacteria to detect, respond and resist environmental insult is a key element in their survival and productivity. The physical and chemical insults to which bacteria may be subject, range from generic stresses, encountered by most unicellular organisms in the environment, to specific stresses encountered by pathogens during infection or by engineering strains during ndustrial bioprocesses. The main objective of this proposal is to develop a profound understanding of the integrative cell management and associated stress resistance processes that are essential for sustaining bacteria as effective pathogens or as efficient producers of pharmaceutically-active proteins.Studies on relevant generic stress responses will be carried out on the genetically highly amenable model bacterium Bacillus subtilis, but will be extended to pathogens in the same (e.g. B. anthracis, B.cereus) and related genera (e.g.Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae). The proposal aims to model the regulatory networks that comprise the Cell Stress Management System, identifying key targets for the development of novel anti-infectives and improving the productivity of Bacillus for the production of biopharmaceuticals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
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Keywords
Call for proposal
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
STREP - Specific Targeted Research ProjectCoordinator
NEWCASTLE UPON TYNE
United Kingdom