Objective It is increasingly being recognised that progress of modern day biology will require the understanding and harnessing the network of interactions between genes and proteins and the functional systems that they generate. Given the complexity of even the most primitive living organism, and our still very limited knowledge, it is unreasonable to expect that we might, in the near or even medium term, reach such understanding the level of an entire cell. However, significant progress towards a system-level understanding should be achievable by applying an integrated approach to the analysis of a set of well defined and biologically important cellular process. Our project aims to bring computer models and simulations to the experimental community. To do so we will focus on two systems that involve different aspects of Biological systems: Networks and Self-organization and we will apply different simulation approximations to both of them. This will enable us both to identify the modelling and simulation strategies that are better suited for a particular experimental problem. The present 3-year project combines a unique group of experimentalists, bioinformaticians and simulation groups in order to gain detailed understanding of key processes: the P53-MDM2 regulatory network and the self organization process whereby chromatin controls microtubule nucleation and organization. A major objective will be to benchmark the ability of current modelling and simulation methods to generate useful hypothesis for experimentalists and to provide new insights into biological processes of realistic complexity. The expected result will be a set of guidelines, specifying which and how simulation methods should be used, given the problem at hand. This should make a fundamental contribution to the area of functional genomics, and provide ways for elucidating the mechanisms of action of pharmacological compounds. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncology Keywords & Biology Computer Computer Modelization Design Evaluation Gene Gene & Protein networks Gradients Modelization Network Network Design Protein Software Software Evaluation Systems Systems Biology networks Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator CENTER FOR GENOMIC REGULATION Address Passeig maritim 37-49 Barcelona Spain See on map Links Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 0,00 Address Serrano, 117 Madrid See on map Links Website Opens in new window Other funding No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 0,00 Address Herzel street 2 Rehovot See on map Links Website Opens in new window Other funding No data UNIVERSITÉ LIBRE DE BRUXELLES Belgium EU contribution € 0,00 Address Avenue f.roosevelt, 50 Bruxelles See on map Links Website Opens in new window Other funding No data FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS Spain EU contribution € 0,00 Address Sinesio delgado, 6 Madrid See on map Links Website Opens in new window Other funding No data "BEREICH HUMANMEDIZIN" GEORG-AUGUST-UNIVERSITY GOETTINGEN Germany EU contribution € 0,00 Address Robert-koch-str. 40 3742/43 Göttingen See on map Links Website Opens in new window Other funding No data BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS Hungary EU contribution € 0,00 Address Müegyetem rkp. 3 Budapest See on map Links Website Opens in new window Other funding No data PARC CIENTIFIC DE BARCELONA Spain EU contribution € 0,00 Address Baldiri reixac, 10-12 Barcelona See on map Other funding No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 0,00 Address Meyerhofstrasse 1 Heidelberg See on map Links Website Opens in new window Other funding No data