Objective
It is increasingly being recognised that progress of modern day biology will require the understanding and harnessing the network of interactions between genes and proteins and the functional systems that they generate. Given the complexity of even the most primitive living organism, and our still very limited knowledge, it is unreasonable to expect that we might, in the near or even medium term, reach such understanding the level of an entire cell. However, significant progress towards a system-level understanding should be achievable by applying an integrated approach to the analysis of a set of well defined and biologically important cellular process. Our project aims to bring computer models and simulations to the experimental community. To do so we will focus on two systems that involve different aspects of Biological systems: Networks and Self-organization and we will apply different simulation approximations to both of them. This will enable us both to identify the modelling and simulation strategies that are better suited for a particular experimental problem. The present 3-year project combines a unique group of experimentalists, bioinformaticians and simulation groups in order to gain detailed understanding of key processes: the P53-MDM2 regulatory network and the self organization process whereby chromatin controls microtubule nucleation and organization. A major objective will be to benchmark the ability of current modelling and simulation methods to generate useful hypothesis for experimentalists and to provide new insights into biological processes of realistic complexity. The expected result will be a set of guidelines, specifying which and how simulation methods should be used, given the problem at hand. This should make a fundamental contribution to the area of functional genomics, and provide ways for elucidating the mechanisms of action of pharmacological compounds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.