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Prostate cancer integral management approach

Objective

In the European Union ~ 200.000 men will be diagnosed with prostate cancer and that number is likely to increase due to the aging population. If the disease is truly localized, patients can be cured by radical local treatment. However, if the malignant process has locally or distantly spread, no curative medical intervention is currently available.

Since the early 1940-ties hormonal therapy has been the main stay in an attempt to control prostate neoplasms, but unfortunately this is only of palliative nature and tumour progression due to the expansive growth of cancer cells that are unresponsive to the currently available hormone therapies is inevitable. Prostate cancer has a strong tendency to spread to the bone, hence in order to combat the disease we have to explore the pathways that lead to hormone therapy unresponsive bone metastatic disease.

It has become clear that in the majority of advanced prostate cancers the androgen receptor signalling pathway is active even in the absence of androgens. EC research teams have a leading role in AR research and will integrate their efforts to exploit androgen receptor mediated signalling as a therapeutic target. These teams will join forces with investigators that study the interaction between prostate cancer cells and the bone micro-environment. The exploration of the pathways leading to hormone therapy unresponsive bone metastatic disease will use functional genomics and expression profiling as technology platforms.

These will also be used to identify new targets. This will ultimately lead to the establishment of assays to identify new (lead) compounds. These new drugs can be tested for their efficacy in models for bone metastatic prostate cancer; hence translation of our knowledge into therapeutic strategies will also be integrated in this consortium to effectively combat prostate cancer.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein-zuid 10
Nijmegen
Netherlands

Participants (16)

CENTRE DE RECHERCHE POUR LES PATHOLOGIES PROSTATIQUES
France
Address
Rue De Capitaine Feber, 60
Paris
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET EN MEDICINE (GIE)
France
Address
1 Rue Laurent Fries
Illkirch
COMPOUND HANDLING B.V.
Netherlands
Address
Kluyverweg 6
Delft
ERASMUS MEDICAL CENTRE
Netherlands
Address
Dr. Molewaterplein 40
Rotterdam
FORSCHUNGSZENTRUM KARLSRUHE GMBH
Germany
Address
Weberstrasse 5
Karlsruhe
LEIDEN UNIVERSITY MEDICAL CENTRE
Netherlands
Address
Albinusdreef 2
Leiden
MEDIZINISCHE UNIVERSITÄT INNSBRUCK
Austria
Address
Innrain 52
Innsbruck
SPECIALITY CHEMICAL SERVICES HOLDING B.V.
Netherlands
Address
Delftechpark 30
Delft
THE CHANCELLORS MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
UNIVERSITY OF BERN
Switzerland
Address
Hochschulstrasse 4
Bern
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address
6 Kensington Terrace
Newcastle Upon Tyne
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Firth Court, Western Bank
Sheffield
UNIVERSITY OF TAMPERE
Finland
Address
Kalevantie 4
Tampere
UNIVERSITY OF TURKU
Finland
Address
Itainen Pitkakatu 4A
Turku
UNIVERSITY OF YORK
United Kingdom
Address
Heslington
York
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzl Street
Rehovot