Objective BIOSCOPE will develop new scale-scale tools allowing unprecedented insight into bio-molecular mechanisms at biological interfaces on the scale of single molecules. The key element in the BIOSCOPE strategy is to involve the bimolecular system itself as part of the baroscopic instrument which in various ways reports to the out-side world about its current local state. BIOSCOPE benefits from the synergy between recent advances in Nan technology and the adaptive dynamic behaviour of many natural and artificial biological systems, which change their structure, physical chemical state and properties as a reaction to the local baroscopic environment.The objectives of BIOSCOPE are1.) To develop instrumentation and methods for manipulation of enzymes and enzyme activity at the scale-scale providing insight into the bimolecular mechanisms on a single molecule level.2.) To develop novel forms of integration, at the level-level, of enzymes and non-biological systems such as Nan particles, artificial membranes, electrical field or force field traps.3.) To confine several enzymes to surfaces of nanoparticles or membranes on a less than 10 nm scale in order to achieve a self-organized assembly with concerted as well as controllable bioaction superior to the simple sum of the same individual enzymes. This addresses NMP area 3.4.1.4 3.4.1.1 and 3.4.1.2.The impact of BIOSCOPE is indeed envisaged as a long-term not only by providing new tools for the scientist, but also by making possible the rational design of new enzymes (and other proteins) based on their true bio-molecular mechanism. The knowledge-base provided by BIOSCOPE will allow researchers and industries to move from design of bimolecular systems based on end-state global properties, which is just one, some times distant, consequence of the true bimolecular mechanism. BIOSCOPE will provide new leads for major break-through in analyses and syntheses, which in turn will lead to the creation of several new SME. Fields of science natural sciencesphysical sciencescondensed matter physicssoft matter physicsengineering and technologynanotechnologynano-materialsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords Biomolecular mechanisms Nanotechnology enzyme molecular structures single molecules supra Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2002-3.4.1.1-3 - Molecular and bio-molecular mechanisms and engines NMP-2002-3.4.1.4-1 - Handling and control instrumentation at the level of of single atoms or molecules and/or < 10 nm Call for proposal FP6-2002-NMP-1 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator LUNDS UNIVERSITET Address Paradisgatan 5c 117 Lund Sweden See on map EU contribution € 0,00 Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all KOBENHAVNS UNIVERSITET Denmark EU contribution € 0,00 Address Noerregade 10 Koebenhavn k See on map NOVOZYMES A/S Denmark EU contribution € 0,00 Address Krogshoejvej 36 Bagsvaerd See on map KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 0,00 Address Oude markt 13 Leuven See on map THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 0,00 Address Senate house, abercromby square Liverpool See on map LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 0,00 Address Geschwister-scholl-platz 1 Muenchen See on map BIOCHEMIJOS INSTITUTAS Lithuania EU contribution € 0,00 Address Mokslininku 12 Vilnius See on map SYDDANSK UNIVERSITET Denmark EU contribution € 0,00 Address Campusvej 55 Odense m See on map STICHTING KATHOLIEKE UNIVERSITEIT Netherlands EU contribution € 0,00 Address Geert grooteplein, 10 Nijmegen See on map Links Website Opens in new window
