Objective
Background: Rheumatoid arthritis (RA) and Multiple Sclerosis (MS) are chronic inflammatory diseases, which are caused by genetic and environmental factors. Susceptible genes have been hard to find in man because of complex genetics of the diseases and the human population. Fortunately, good animal models are available. Pristine induced arthritis and experimental allergic encephalomyelitis in rats are such models. These models have been used to investigate the linkage of genome regions to disease phenotype in crosses between the susceptible DA rat and the resistant E3 rat. In these experiments a number of regions controlling disease onset, severity rend tonicity have been identified. Interestingly, several of these regions affect disease both in RA and MS. All major. Regions have been isolated as congener fragments in rats that will now be used to position ally clone the responsible genes. This project will focus on congener rats specifically controlling chronic inflammation. Cloning will be achieved by recombination selection complemented by new technologies in functional genomic and polemics. Objectives: To position ally clone gene(s) controlling tonicity in rat models of RA and MS and to elucidate the biological pathways affected by these genes. This knowledge will be used for development of new therapies for chronic inflammatory diseases. Methods: The project will be performed on genetically unique rats at the section for Medical Inflammation Research in Sweden. The genes will be cloned by recombination selection strategies witch are complemented by new techniques like micro array, real time PCR and 2D electrophoresis followed by mass-spectrometry, which are highly valuable and suitable for studies on complex diseases in animal models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences health sciences inflammatory diseases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology multiple sclerosis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.